Investigating the risk of recurrent cervical artery dissection after pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine if pregnancy increases the risk of recurrent cervical artery dissection (CeAD) and delayed stroke in women who have previously experienced CeAD. It will utilize pooled individual patient data from multiple stroke centers, focusing on long-term follow-up of women with prior CeAD. The primary endpoint includes the occurrence of recurrent CeAD, ischemic or hemorrhagic stroke, and death. The study will also explore the impact of delivery mode on recurrence and whether women chose to avoid pregnancy due to their initial CeAD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* female
* prior symptomatic cervical artery dissection (= index CeAD)
* at least one long-term follow-up visit (at least 6 months after the initial event)
* with information available on outcome events:
* recurrent dissection
* ischemic stroke
* hemorrhagic stroke
* functional outcome assessed by mRS score
* with data on pregnancy after the initial event
* at least 18 years old at the initial event

Exclusion Criteria:

* Male patients
* Age \<18 years
* No long-term follow-up available or long-term follow-up \< 6 months after initial event
* No data on pregnancy after initial event available

Where it's running

• University of Utah
  Salt Lake City, Utah, United States Recruiting
• University of Virginia
  Charlottesville, Virginia, United States Recruiting
• Stroke Unit Sanatorio Allende
  Córdoba, Argentina Recruiting
• Department of Neurology, Medical University of Innsbruck
  Innsbruck, Tyrol, Austria Recruiting
• Helsinki University Central Hospital
  Helsinki, Finland Recruiting
• Charité Universitätsmedizin, Centrum für Schlaganfallforschung
  Berlin, Germany Recruiting

Study contacts

• Principal investigator: Stefan T Engelter, MD — University Hospital, Basel, Switzerland
• Study coordinator: Stefan T Engelter, MD
• Email: stefan.engelter@felixplatter.ch
• Phone: +41 61 326 41 05

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.