Using prenatal ultrasound to predict placental condition at birth.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This two-phase observational project first analyzes archived prenatal ultrasounds and linked placental pathology from past deliveries to develop image-processing markers of placental injury. In the prospective phase, researchers will enroll pregnant people with singleton gestations who have fetal growth restriction at 20–28 weeks and a matched group with normal growth at 36–38 weeks to collect standardized ultrasounds and compare findings to placental histology at delivery. The team will search for ultrasound signatures associated with Amsterdam-classified placental lesions such as maternal or fetal vascular malperfusion and inflammation. The overall aim is to determine whether antepartum ultrasound can identify placental injury patterns that predict adverse outcomes.

Why it matters

Who can join: the full rules

Retrospective Phase

Inclusion criteria:

* Patients with delivery in NorthShore University HealthSystem,
* Ultrasound available within 4 weeks of delivery with adequate placental images
* Placental pathology available

Exclusion criteria:

* Multiple gestation

Prospective Phase Inclusion criteria

* Exposed: Patients with singleton gestation with fetal growth restriction at 20-28 weeks with a plan to deliver at NorthShore Highland Park Hospital Evanston Hospital. Patients must have a first-trimester ultrasound (\<14 weeks) to confirm pregnancy dating available in the electronic medical record.
* Unexposed: Patients who present for routine ultrasound evaluation at 36-38 weeks with normal fetal growth with a plan to deliver at NorthShore Highland Park Hospital or NorthShore Evanston Hospital.

Exclusion criteria:

* Exposed: Multiple gestation, major fetal anomaly
* Unexposed: Multiple gestation, history of chronic hypertension, gestational or pregestational diabetes, major fetal anomaly antiphospholipid syndrome, known thrombophilia

Where it's running

• NorthShore University HealthSystem
  Evanston, Illinois, United States Recruiting

Study contacts

• Principal investigator: Sunitha Suresh — Endeavor Health
• Study coordinator: Sunitha Suresh
• Email: SSuresh@northshore.org
• Phone: 8475702860

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.