Pregnancies before a lupus diagnosis
Pregnancy Outcomes Prior to a Systemic Lupus Erythematosus Diagnosis
See if pregnancies that happened before women were diagnosed with lupus showed early lupus signs and how those pregnancies affected mothers and babies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | Female |
| Sponsor | University of Algiers Academic / other |
| Locations | 2 sites (Aïn Taya, Algiers Province and 1 other locations) |
| Trial ID | NCT07148115 on ClinicalTrials.gov |
What this trial studies
This is a retrospective, single-center cohort using medical record review and brief participant interviews to collect obstetrical and systemic data from pregnancies that occurred before a later diagnosis of systemic lupus erythematosus (SLE). Investigators will include women classified as having SLE by ACR 1997 or EULAR 2019 criteria and extract details on each pregnancy, maternal and fetal outcomes, and any systemic or obstetrical signs noted during or before pregnancy. The analysis will describe the presence of prediagnostic systemic signs, report pregnancy outcomes (for example miscarriage, preterm birth, fetal loss), and summarize SLE severity after diagnosis. Results aim to identify patterns that might signal undiagnosed SLE during pregnancy and inform future monitoring and counseling.
Who should consider this trial
Good fit: Women diagnosed with SLE after at least one pregnancy, who meet ACR 1997 or EULAR 2019 criteria and can provide access to their pregnancy medical records and attend the Ain-Taya clinic, are the intended participants.
Not a fit: Women diagnosed with SLE before any conception, those without accessible pregnancy records, or those unable to attend the Ain-Taya site are unlikely to receive benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help clinicians spot early SLE signs during pregnancy and improve monitoring and counseling for affected mothers and future pregnancies.
How similar studies have performed: Previous retrospective cohorts have suggested obstetrical complications and prediagnostic systemic signs can precede SLE diagnosis, but published data are limited and not definitive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Women of childbearing age with a history of at least one pregnancy * Pregnancy occurred before the diagnosis of LES. * LES was diagnosed after at least one pregnancy. * The subject is classified as having LES according to the 1997 ACR or EULAR 2019 criteria. Exclusion criteria: LES was previously diagnosed prior to any conception.
Where this trial is running
Aïn Taya, Algiers Province and 1 other locations
- Department of internal medicine, Ain-Taya's teaching Public hospital — Aïn Taya, Algiers Province, Algeria (Active_not_recruiting)
- Ain-Taya's Public Hospital — Algiers, Algeria (Recruiting)
Study contacts
- Study coordinator: Wafia- Nadia Nibouche - Hattab, Professor in medicine
- Email: wani16000@yahoo.fr
- Phone: +213-771-810-932
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.