Effects of low dose aspirin on immunity during pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate how low dose aspirin (LDA) affects the immune system in pregnant women at high risk for preeclampsia (PE). It will assess the modulation of various immune cells and quantify pro-inflammatory and anti-inflammatory cytokines before and after LDA administration. The study will include singleton pregnancies monitored at the Centro Hospitalar e Universitário de Coimbra, with participants classified as high-risk for PE based on specific clinical criteria. The study will last between 40 weeks and 24 months, focusing on maternal and fetal outcomes in comparison to low-risk pregnancies.

Why it matters

Who can join: the full rules

Inclusion Criteria: - Singleton pregnancy

* Patients attending prenatal consultations at the Obstetrics Service A of CHUC, with the first consultation occurring before 14 weeks of gestation
* Gestational age determined by first-trimester ultrasound
* Study group: Women classified as high risk for PE according to clinical/historical criteria and the Fetal Medicine Foundation algorithm. LDA-naïve.

Exclusion Criteria: Multiple pregnancy

* Autoimmune diseases
* Prior use of LDA or other immunomodulatory medication before potential recruitment
* History of spontaneous miscarriages and/or medical termination of pregnancy
* Fetal malformation

Where it's running

• Unidade Local de Saúde de Coimbra, E.P.E.
  Coimbra, Coimbra District, Portugal Recruiting

Study contacts

• Principal investigator: Ana L Areia, PhD MD — University of Coimbra
• Study coordinator: Ana L Areia, PhD, MD
• Email: analuisareia@gmail.com
• Phone: +351917212222

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.