Mouth bacteria, gum disease, and oral HPV in people living with HIV
Oral microbiome and periodontal diseases in oral HPV infection among people living with HIV
This project looks at whether mouth bacteria and gum disease are linked to getting or keeping oral HPV in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11158633 on NIH RePORTER |
What this research studies
You would be asked to provide oral swabs and undergo a dental exam so researchers can map the bacteria in your mouth and check gum health. They will test samples for oral HPV and measure immune markers that might explain why HPV persists or clears. The team will compare people with different oral microbiome and periodontal profiles and follow HPV status over time. Laboratory methods will include microbial DNA sequencing and immune assays tied to clinical exams and medical history.
Who could benefit from this research
Good fit: Adults living with HIV who can attend Emory-affiliated clinic visits and are willing to provide oral samples and dental exam information are ideal candidates.
Not a fit: People without HIV, children, or anyone unwilling/unable to provide oral samples or attend clinic visits would not be expected to benefit from participating.
Why it matters
Potential benefit: If successful, the work could point to new ways to prevent or detect oral HPV and reduce risk of throat cancers in people living with HIV.
How similar studies have performed: Some studies in people without HIV have suggested links between oral microbes, gum disease, and oral HPV, but research specifically in people living with HIV is limited, making this work relatively novel for that population.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Xiao, Canhua — Emory University
- Study coordinator: Xiao, Canhua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.