Effect of Periodontal Therapy on Gut Microbes and Inflammation in People with Inflammatory Bowel Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational prospective study conducted at CIR Dental School in Turin, led by the University of Turin. It will observe adults with ulcerative colitis or Crohn's disease who have stage III or IV periodontitis to see how conventional periodontal treatment affects their gut microbiome and systemic inflammatory parameters. The research focuses on the oral-gut axis and its potential role in chronic inflammatory conditions. No interventional arms beyond standard periodontal therapy are described, and the study aims to identify associations between periodontal health improvements and gut-related outcomes. Results may inform future trials and understanding of how oral health relates to IBD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* clinical and instrumental diagnosis of ulcerative colitis or Crohn's disease
* periodontitis Stage III or IV
* BMI between 20 and 29 kg/m2
* free diet
* presence of at least 20 teeth

Exclusion Criteria:

* systemic diseases (including diabetes, thyroid, liver, or kidney diseases)
* dietary allergies
* use of antibiotics or probiotics during the previous 30 days
* pregnancy or breastfeeding

Where it's running

• CIR Dental School
  Turin, Turin, Italy Recruiting

Study contacts

• Study coordinator: Mario Aimetti MA Prof.
• Email: mario.aimetti@unito.it
• Phone: +39 0116331541

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.