Using a new dental gel to improve gum health after cleaning

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of Livionex Dental Gel (LDG) as a home care product to enhance the results of scaling and root planing (SRP) in patients with periodontitis. SRP is a standard dental procedure aimed at removing plaque and tartar from teeth to alleviate gum disease. The study aims to determine if the addition of LDG can further reduce probing pocket depth beyond what is achieved with SRP alone. Participants will be monitored for their oral health and adherence to the treatment protocol throughout the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female subjects at least 18 years of age.

  * Subject must be willing and able to provide written informed consent.
  * Available during the course of the study.
  * Must have minimum of 20 natural teeth, excluding third molars.
  * Must have at least 20 BOP sites, excluding third molars.
  * Stage II or III, Grade B periodontitis with at least 4 teeth with a minimum PD of 5 mm and minimum CAL of 3mm.
  * No antibiotic therapy for periodontal disease or chronic use of anti-inflammatory drugs (NSAIDs) within the past month of Baseline, or during the study.
  * Must not have received definitive treatment (i.e., SRP or periodontal surgical therapy) for periodontitis in the last one year.
  * Subject must be willing and able to comply with study visits as described in the protocol.
  * Subjects must be available for follow up on the telephone.
  * Able to read and understand the consent form in English

Exclusion Criteria:

* • Pregnancy or breast feeding.

  * Medical condition that requires pre-medication prior to dental procedures.
  * Systemic conditions and use of medications that may affect periodontal tissues.
  * Severe dental disease characterized multiple decayed, untreated dental sites.
  * Presence of orthodontic appliances.
  * Diseases of oral soft or hard tissues.
  * Participating in another clinical trial currently or in the month preceding this study.
  * Stage IV and/or Grade C periodontitis.
  * Vertical bone defects 4mm or greater.
  * Subjects who have active dental infections other than periodontitis that will require dental treatment during the study period.
  * Excessive oral hygiene practices including use of water irrigation devices such as Waterpik or use of interdental cleansers more than twice daily.
  * Non-English speaking
  * Smokers, uncontrolled or brittle diabetics, HIV/AIDS, and subjects with severe systemic disease, e.g., cancer, lupus, pemphigus vulgaris/pemphigoid, or other oral mucous membrane diseases that would interfere with performance of oral hygiene, e.g., erosive lichen planus, recurrent major aphthous lesions, etc.
  * History of allergic reaction to any ingredient in the test/control dentifrices.
  * Presence of any condition, abnormality, or situation at Baseline that in the opinion of the Principal Investigator may preclude the subject's ability to comply with study requirements, including completion of the study or the quality of the data.
  * Subjects unwilling to use manual toothbrush during the study.

Where it's running

• Unversity of Alabama at Birmingham, School of Dentistry
  Birmingham, Alabama, United States Recruiting

Study contacts

• Study coordinator: Maninder Kaur, BDS,MPH,MS
• Email: maninder@uab.edu
• Phone: 2059344506

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.