Using antibiotics to enhance periodontal treatment effectiveness
Official title: Pharmacokinetic Considerations and Dosing Strategies of Amoxicillin and Metronidazole or Azithromycin as Adjunct to Non-surgical Periodontal Therapy. A Randomized,6-month, Parallel-group, Clinical Trial.
Run by University of Geneva, Switzerland · NCT04669717 · Data updated 2026-11-12
This study is testing different antibiotic treatments to see which ones can help people with gum disease get better after their teeth cleaning.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | University of Geneva, Switzerland Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Geneva, Canton of Geneva) |
| Status | Recruiting |
| Started | September 1, 2021 |
| Main results expected | December 1, 2028 |
| Study ends | December 1, 2028 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT04669717 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-80 with periodontitis requiring antibiotic therapy and significant periodontal disease indicators.
✕Probably not a fit
Patients with systemic illnesses, recent antibiotic use, or those who have undergone periodontal therapy in the last year may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the optimal dosage and duration of antibiotic therapy as an adjunct to mechanical treatment for periodontitis, a disease that causes inflammation and destruction of tooth-supporting tissues. The study involves 45 patients who will receive different antibiotic regimens following mechanical debridement, with clinical and microbiological assessments conducted at various intervals. The goal is to determine the most effective antibiotic strategy to eliminate pathogenic bacteria while minimizing the risk of antimicrobial resistance. The trial is conducted at the University of Geneva and involves collaboration with the University of Lausanne.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatments for periodontitis, improving patient outcomes and reducing the risk of tooth loss.
How similar studies have gone: Previous studies have explored antibiotic adjuncts in periodontal therapy, but this trial aims to refine dosing strategies, making it a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed Consent as documented by signature * Aged 18-80 years old with need of periodontal treatment associated with adjunctive antibiotic therapy * Presence of at least 30% of the teeth in the mouth with PD\>6mm and BOP Exclusion Criteria: * Persons with systemic illnesses (uncontrolled diabetes mellitus, cancer, human immunodeficiency virus, bone metabolic diseases or disorders that compromise wound healing, radiation, or immunosuppressive therapy) * Pregnancy or lactation * Persons who had taken AB within the previous 2 months * Persons who are taking nonsteroidal anti-inflammatory drugs * Persons who have a confirmed or suspected intolerance to 5-nitroimidazole derivatives or amoxicillin or macrolides * Previous periodontal therapy the last 1 year * Known or suspected non-compliance, drug or alcohol abuse * Inability to follow due to language problems, psychological disorders, dementia, etc. of the participant * Participants not willing to attend regular dental maintenance visits and follow-up evaluations * Participation in another study with investigational drug within the 30 days preceding and during the present study
Where it's running
-
University of Geneva, University Clinics of Dental Medicine
Geneva, Canton of Geneva, Switzerland Recruiting
Study contacts
- Principal investigator: Catherine Giannopoulou, Dr med dent — University Clinics of Dental Medicine, University of Geneva
- Study coordinator: Catherine Giannopoulou, Dr med dent
- Email: ekaterini.giannopoulou@unige.ch
- Phone: 0041223794068
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Probiotics vs Antibiotics as an add-on to non-surgical periodontal care in adult smokers with stage II, grade B periodontitis
This study tests whether systemic probiotics or systemic antibiotics added to standard non-surgical periodontal treatment help improve gum health in adult smokers with stage II, grade B periodontitis.
-
Levetiracetam Dosing in Critically Ill on CRRT
This study tests how levetiracetam behaves in the bodies of adults on continuous renal replacement therapy to help figure out the best dosing.
-
Effect of Periodontal Therapy on Gut Microbes and Inflammation in People with Inflammatory Bowel Disease
This study tests whether treating gum disease in people with inflammatory bowel disease can influence the gut microbiome and markers of systemic inflammation.
-
Trigonelline Monohydrate for NAD+ Metabolism in Healthy Adults
A small study in healthy adults tests whether taking trigonelline monohydrate by mouth for 4 weeks can change NAD+ levels and how the body handles the supplement, compared with NMN and placebo.
-
Cetuximab bioequivalence test in healthy men
This study tests whether a cetuximab injection is bioequivalent to Erbitux in healthy men to see if they behave the same in the body.
-
Bacterial Diversity in Gum Health With Fixed vs Removable Retainers After Braces
This study tests the gum microbiome and gum health in adults after braces, comparing fixed lingual retainers to removable Essix retainers.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.