Using antibiotics to enhance periodontal treatment effectiveness
Pharmacokinetic Considerations and Dosing Strategies of Amoxicillin and Metronidazole or Azithromycin as Adjunct to Non-surgical Periodontal Therapy. A Randomized,6-month, Parallel-group, Clinical Trial.
This study is testing different antibiotic treatments to see which ones can help people with gum disease get better after their teeth cleaning.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Geneva, Switzerland Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Geneva, Canton of Geneva) |
| Trial ID | NCT04669717 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the optimal dosage and duration of antibiotic therapy as an adjunct to mechanical treatment for periodontitis, a disease that causes inflammation and destruction of tooth-supporting tissues. The study involves 45 patients who will receive different antibiotic regimens following mechanical debridement, with clinical and microbiological assessments conducted at various intervals. The goal is to determine the most effective antibiotic strategy to eliminate pathogenic bacteria while minimizing the risk of antimicrobial resistance. The trial is conducted at the University of Geneva and involves collaboration with the University of Lausanne.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-80 with periodontitis requiring antibiotic therapy and significant periodontal disease indicators.
Not a fit: Patients with systemic illnesses, recent antibiotic use, or those who have undergone periodontal therapy in the last year may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatments for periodontitis, improving patient outcomes and reducing the risk of tooth loss.
How similar studies have performed: Previous studies have explored antibiotic adjuncts in periodontal therapy, but this trial aims to refine dosing strategies, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed Consent as documented by signature * Aged 18-80 years old with need of periodontal treatment associated with adjunctive antibiotic therapy * Presence of at least 30% of the teeth in the mouth with PD\>6mm and BOP Exclusion Criteria: * Persons with systemic illnesses (uncontrolled diabetes mellitus, cancer, human immunodeficiency virus, bone metabolic diseases or disorders that compromise wound healing, radiation, or immunosuppressive therapy) * Pregnancy or lactation * Persons who had taken AB within the previous 2 months * Persons who are taking nonsteroidal anti-inflammatory drugs * Persons who have a confirmed or suspected intolerance to 5-nitroimidazole derivatives or amoxicillin or macrolides * Previous periodontal therapy the last 1 year * Known or suspected non-compliance, drug or alcohol abuse * Inability to follow due to language problems, psychological disorders, dementia, etc. of the participant * Participants not willing to attend regular dental maintenance visits and follow-up evaluations * Participation in another study with investigational drug within the 30 days preceding and during the present study
Where this trial is running
Geneva, Canton of Geneva
- University of Geneva, University Clinics of Dental Medicine — Geneva, Canton of Geneva, Switzerland (Recruiting)
Study contacts
- Principal investigator: Catherine Giannopoulou, Dr med dent — University Clinics of Dental Medicine, University of Geneva
- Study coordinator: Catherine Giannopoulou, Dr med dent
- Email: ekaterini.giannopoulou@unige.ch
- Phone: 0041223794068
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.