The connection between oral bacteria, gum disease, and HPV infection in people with HIV
Official title: Oral microbiome and periodontal diseases in oral HPV infection among people living with HIV
Funded at Emory University · NIH-10894827 · Data updated 2026-11-12
This study is looking at how the bacteria in your mouth and gum diseases might affect HPV infections in people living with HIV, and it wants to learn how social factors play a role in this, so we can better understand why HPV-related cancers are more common in this group.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 11, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $764,824 |
| NIH project number | 5R01DE032243-03 |
| Project ID | NIH-10894827 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may also be experiencing oral health issues or are at risk for HPV infections.
✕Less likely to help
Patients who do not have HIV or those without any oral health concerns may not benefit from this research.
What this research studies
This research investigates how the oral microbiome and periodontal diseases influence oral HPV infections in individuals living with HIV. It aims to understand the immune responses related to these infections and explore how social factors may affect the oral microbiome and HPV prevalence. By examining the interactions between oral health and HPV, the study seeks to uncover the underlying mechanisms that contribute to higher rates of HPV-related cancers in this population. Participants may undergo assessments of their oral health and microbiome to provide valuable data for the research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for oral HPV infections and related cancers in people living with HIV.
How similar studies have gone: While the specific interactions between the oral microbiome and HPV in people with HIV are not well-studied, related research has shown promising results in understanding oral health impacts on viral infections.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Xiao, Canhua — Emory University
- Study coordinator: Xiao, Canhua
Related research
Other NIH-funded projects on the same topics.
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Oral bacteria, gum disease, and oral HPV in people living with HIV
This project looks at how the mouth’s bacteria and gum disease relate to oral HPV in people with HIV, and what immune factors might be involved.
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Mouth bacteria, gum disease, and oral HPV in people living with HIV
This project looks at whether mouth bacteria and gum disease are linked to getting or keeping oral HPV in people living with HIV.
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Epigenetics of oral HPV-related mouth and throat cancer in people with HIV in Nigeria
This project looks for DNA markers in people living with HIV in Nigeria to find who has or might develop HPV-related mouth and throat cancers.
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Antibodies and vaginal bacteria in HPV-related cervical changes
This project looks at whether antibodies bind different vaginal bacteria in women with HPV or cervical cell changes to understand why some women develop more serious lesions.
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How HIV Treatment Might Change Oral HPV Risk
A study explored how antiretroviral therapy for HIV could affect the mouth’s lining and the chance of catching oral HPV, with participants including people living with HIV on ART and people using ART for PrEP.
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Understanding how the penile cancer microbiome and p16 relate to HPV and outcomes across diverse patients
This project will look at how the tiny microbes living in penile tumors, p16 protein levels, high-risk HPV, and clinical outcomes are connected across patients from different regions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.