Condition

Dental Caries clinical trials and research

• 37Clinical trials
• 27NIH research projects
• 1New in 30 days
• 19Countries

Newest Dental Caries clinical trials

All recruiting trials (37)

• Silver Diamine Fluoride for Caries in Baby Teeth in Routine Dental Care

  This study tests whether applying 38% silver diamine fluoride in everyday dental practice can stop decay in primary teeth of children 14 and younger.

  Recruiting Consorci Sanitari de l'Alt Penedès i Garraf · Vilanova i la Geltrú, Barcelona · NCT07926828

• Nano Silver Fluoride vs. Silver Diamine Fluoride for Kids’ Cavities

  This study tests whether Nano Silver Fluoride can stop decay in children as well as Silver Diamine Fluoride.

  Recruiting A.T. Still University of Health Sciences · Mesa, Arizona · NCT07861321

• Digital Caries Risk Questionnaire: does it match CAMBRA in Egyptian adults

  A digital self‑administered caries risk questionnaire is being tested to see how well it matches the CAMBRA risk assessment in Egyptian adults who visit the dentist.

  Recruiting October University for Modern Sciences and Arts · Giza, Sixth of October · NCT07716254

• First permanent molars restored with Cention N in children

  This trial tests whether restoring both first permanent molars with Cention N in children aged 8-10 is beneficial for clinical results, x-ray findings, and daily oral health quality of life over 12 months.

  Recruiting Minia University · Minya, Asyut Governorate · NCT07703176

• Ozone therapy to boost remineralization of early caries in kids

  This study tests whether adding ozone therapy to a remineralizing gel helps children aged 6–12 remineralize early, non-cavitated caries lesions better than the gel alone.

  Recruiting Marmara University · Istanbul, Maltepe · NCT07671651

• Dental health in children with specific learning disabilities

  This study will test the dental caries and oral hygiene of 7–12 year-olds with specific learning disabilities and compare them with healthy peers.

  Recruiting Alanya Alaaddin Keykubat University · Alanya, Antalya · NCT07611981

• Effect of fluoride varnish and chlorhexidine on saliva biomarkers in children with and without active caries

  The study tests whether salivary IL-6 and matrix metalloproteinases change after fluoride varnish alone or fluoride varnish with chlorhexidine in kids with active caries compared with caries-free children.

  Recruiting Alanya Alaaddin Keykubat University · Alanya, Antalya · NCT07609797

• Digital and AI tools for detecting dental cavities in adults

  This project will test whether digital and AI-based tools can detect dental cavities more accurately than standard visual exams and bitewing X-rays in adults with permanent teeth.

  Recruiting University Hospital, Martin · Martin, Žilina Region · NCT07560514

• Intraoral scanning and CBCT for detecting dental plaque and cavities

  This project tests whether intraoral scans and CBCT can accurately detect dental plaque and cavities in adults aged 18 to 70.

  Recruiting University Hospital, Ghent · Wondelgem, Botestraat · NCT07555223

• Comparing a bioactive bulk-fill layer plus microhybrid versus microhybrid alone for Class II back-tooth restorations

  This study will test whether placing a bioactive bulk-fill layer under a standard microhybrid filling leads to better fit, retention, and less staining for adults who need two similar Class II back-tooth restorations.

  Recruiting Bezmialem Vakif University · Istanbul · NCT07547904

• Periodontal ligament-integrated implant to restore tooth-like mobility and sensation

  This trial will try a new dental implant that uses leftover periodontal ligament tissue to replace a single-rooted tooth in adults and see if it restores natural tooth movement and feeling.

  Recruiting at 2 sites OrganTech, Inc. · Kōriyama, Fukushima and 1 other locations · NCT07302581

• Adaptive school-based interventions to prevent dental caries in children

  This study tests personalized, stepwise prevention strategies in schools to see if they can reduce tooth decay in children aged 5–13.

  Recruiting Phase 3 University of Pennsylvania · Glenwood Springs, Colorado · NCT07265830

• MI Paste Plus for lowering Streptococcus mutans and preventing white spot lesions during fixed orthodontic treatment

  This trial will test whether daily application of MI Paste Plus reduces Streptococcus mutans levels and prevents white spot lesions in people aged 5–45 who wear fixed braces.

  Recruiting Cardenal Herrera University · Tirana, Albania and 1 other locations · NCT07244991

• Oral-spray Bacillus Probiotics to Help Prevent and Support Treatment of Cavities in Children

  A probiotic spray containing Bacillus subtilis ANA48 and Bacillus clausii ANA39 is being tested in 7- to 10-year-old children to see if it helps prevent cavities and support dental treatment.

  Recruiting Anabio R&D · Hà Nội, Sơn Tây · NCT07241052

• Long-term comparison of two treatments for tooth decay in older adults

  This project will test whether twice-yearly silver diamine fluoride works as well as atraumatic restorative treatment with fluoride varnish for preventing and treating tooth decay in older adults who participated in a prior housing-based study in Northeast Ohio.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07213661

• Fast versus standard light-curing for composite fillings in baby molars

  This test tries whether a very quick 5-second high-intensity light cure or the usual 10-second cure is safe and works well for composite fillings in primary molars in young children.

  Recruiting at 2 sites Ivoclar Vivadent AG · Herzogenbuchsee, Canton of Bern and 1 other locations · NCT07212660

• Silver diamine fluoride vs fluoride varnish to lower Streptococcus mutans in children

  This trial will see if applying 38% silver diamine fluoride on one side of the mouth and 5% fluoride varnish on the other lowers Streptococcus mutans in children aged 3–8 with bilateral cavities.

  Recruiting Assiut University · Asyut, Asyut Governorate · NCT07181967

• Bite effects of Hall crowns on baby molars

  This trial tests whether placing Hall crowns on different primary molars changes a child's bite, using digital intraoral scans to measure differences.

  Recruiting Ankara Yildirim Beyazıt University · Ankara, Keçiören · NCT07134114

• Comparing a dental anesthesia injector versus the traditional syringe for numbing upper baby molars in children

  This trial tests whether a dental anesthesia injector causes less pain and anxiety than a regular syringe in 6–8-year-old children needing local anesthesia for pulpotomy.

  Recruiting at 2 sites Ain Shams University · Cairo, Cairo Governorate and 1 other locations · NCT07101068

• Comparing partial tooth restorations made with 3D printing versus CAD-CAM

  This project will try two types of partial tooth restorations—one 3D-printed and one made with CAD-CAM—in people who need restorations on two teeth to see which one performs better using FDI clinical criteria.

  Recruiting Cukurova University · Adana, Sarıçam · NCT07031856

• Longitudinal Minimally Invasive Dental Caries Protocols in Brazilian Schoolchildren

  This study tests minimally invasive dental treatments for active caries in 6–12 year-olds in Brazilian public schools to see if these approaches prevent progression over 24 months.

  Recruiting University of Nove de Julho · Santos, São Paulo · NCT06999005

• Archaea and tooth decay

  This project tests whether certain archaea in saliva and cavity tissue are linked to tooth decay in adults treated at the Timone dentistry clinic.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT06787261

• Mothers' Action Project to prevent early tooth decay and reduce obesity risk in young children

  This 12-month program will try group education and social-network support for South Asian mothers with young children to reduce early childhood tooth decay and lower obesity risk.

  Recruiting University of Massachusetts, Worcester · New York, New York · NCT06753669

• Probiotic treatment for orthodontic patients

  This study is testing if a probiotic lozenge can help reduce dental plaque and cavities in healthy orthodontic patients wearing braces.

  Recruiting University of Aarhus · Aarhus · NCT06751979

• Using a new dental treatment for cavities in adults

  This study is testing a new dental treatment for cavities in adults to see if it can safely help fix teeth without causing any harm.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06727110

• Community-based hydration intervention in schools

  This study is testing a program in schools to see if adding water stations helps students drink more water, stay healthier, and improve their overall well-being.

  Recruiting Virginia Commonwealth University · Henrico, Virginia · NCT06714929

• Comparing white dental crowns to metal crowns for children's teeth

  This study tests if a new flexible white dental crown works just as well as the traditional metal crown for young children needing dental work.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT06713330

• Effect of Silver Diamine Fluoride on Oral Microbiome in Children

  This study is testing whether silver diamine fluoride alone or with potassium iodide can help stop cavities in healthy children aged 4-10 and how these treatments affect the germs in their mouths.

  Recruiting Phase 4 King Abdulaziz University · Jeddah, Mecca Region · NCT06699199

• Comparing stainless steel and zirconia crowns for children's teeth

  This study is testing whether stainless steel crowns or zirconia crowns work better and make parents happier for kids aged 4 to 5 who need dental crowns on their back teeth.

  Recruiting Aydin Adnan Menderes University · Aydin, Aydın · NCT06685640

• Using technology and peer support to help parents prevent early childhood dental issues

  This study is testing if a new program that uses technology and support from other parents can help moms and dads prevent dental problems in their young kids better than regular education.

  Recruiting National University of Singapore · Singapore · NCT06558955

• Improving Oral Health for Older Adults in Primary Care

  This study is testing whether better training for doctors and changes to their systems can help older adults on Medicaid get more dental care and improve their oral health.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT06555029

• Assessing long-term dental effects of chemotherapy in childhood cancer survivors

  This study looks at the long-term dental health of childhood cancer survivors who had chemotherapy to see if they have more dental problems compared to kids who didn’t have cancer.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels · NCT06517927

• Vitamin D supplementation for dental caries treatment

  This study is testing whether vitamin D supplements can help people aged 12 to 45 with early tooth decay get better compared to those using fluoride treatments.

  Recruiting Phase 4 Dow University of Health Sciences · Karachi, Sindh · NCT06172764

• Using intraoral scanners to diagnose dental and periodontal diseases

  This study tests whether using a special 3D scanner can help dentists diagnose tooth and gum diseases more accurately and quickly than traditional methods for patients with gum issues.

  Recruiting CHU de Reims · Reims · NCT06006429

• Health education interventions to prevent dental issues in orthodontic patients

  This study tests two different ways of teaching young people with braces about oral health to see which one helps them avoid cavities and gum disease better.

  Recruiting Universidad Nacional de Colombia · Bogotá · NCT05979805

• Free dental treatment for patients in substance abuse rehabilitation

  This study tests whether offering free dental care to people in substance abuse rehab helps them use the services and supports their recovery process.

  Recruiting University Hospital of North Norway · Narvik, Nordland · NCT05606562

• Using optical coherence tomography to evaluate dental treatments

  This study is testing a new imaging technology to see if it can help improve dental treatments with sealants for braces and monitor their effects on tooth health over time.

  Recruiting University of Heidelberg Medical Center · Heidelberg · NCT03753256

NIH-funded research (27)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how buprenorphine in the mouth could affect dental health

  This NIH grant investigates why buprenorphine, taken for opioid use disorder, may harm teeth and how to prevent it for people using this treatment.

  NIH research University of Houston · Houston, United States · NIH-11391283

• Fluoridated bottled water to prevent cavities in young children

  A large, patient-facing trial tests whether having fluoridated drinking water in bottled form can prevent tooth decay in children from infancy to early childhood.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11364274

• Why under-the-tongue buprenorphine may harm teeth

  This project looks at how buprenorphine taken under the tongue may cause tooth damage in people treated for opioid use disorder.

  NIH research University of Houston · Houston, United States · NIH-11354393

• Understanding how Streptococcus mutans builds sugars that drive tooth decay

  Researchers will study how the tooth decay bacteria S. mutans makes different sugar polymers, aiming to uncover why these polymers help the bacteria stick to teeth and cause dental caries.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11333043

• Understanding how dental cavities change over the nation using smart statistics

  A nationwide study will use advanced statistical methods to better understand how dental caries develop and vary across the U.S., based on NHANES data.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11321658

• Bacterial genes linked to severe childhood cavities

  This project looks at specific genes in the cavity-causing bacterium Streptococcus mutans to learn why some strains lead to severe tooth decay in young children.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11306610

• Bacteriophages as a therapy for dental caries

  A patient-facing project is exploring whether harmless viruses that attack bacteria can help prevent or treat tooth decay in people of all ages, including children.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11292545

• A new way to deliver fluoride for stronger teeth

  This project explores a new plasma technology to deliver fluoride more effectively into tooth enamel to help prevent cavities.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11247629

• Understanding the connection between early life stress, the mouth's germs, and cavities in children

  This research explores how stressful childhood experiences might affect the balance of germs in a child's mouth, leading to cavities.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11193504

• Understanding how a bacteria causes tooth decay

  This study is looking at how a common bacteria called Streptococcus mutans causes tooth decay by using special enzymes to stick to your teeth and create harmful sugars, with the hope of finding better ways to prevent or treat cavities.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11167778

• Fluoridated bottled water to help prevent cavities in young children

  This project gives fluoridated bottled water to infants and young children in a community without fluoridated tap water to try to reduce tooth decay.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11160465

• Understanding Which Parts of Dental Treatments Work Best for Children

  This project aims to create new ways to understand which specific parts of a complex dental treatment are most effective for children.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11159711

• Targeting acid-making mouth bacteria to prevent tooth decay

  This work is creating mouth-safe treatments that turn on in acidic spots to reduce cavity-causing bacteria for people at risk of tooth decay.

  NIH research Ada Forsyth Institute, INC. · Somerville, UNITED STATES · NIH-11159638

• Understanding dental caries outcomes using national health data

  This study is looking at ways to better understand dental cavities by using smart math techniques on health survey data, so that everyone can get better treatment based on their specific dental health needs.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11139804

• Examining the links between tooth decay and gum disease

  This study is looking at how tooth decay and gum disease are connected and how things like age, gender, and income might play a role, so we can find better ways to take care of your dental health.

  NIH research University of Florida · Gainesville, United States · NIH-11130505

• Targeting a specific enzyme in bacteria to prevent tooth decay

  This study is looking at a new way to help prevent cavities by targeting a specific enzyme in the bacteria that cause tooth decay, aiming to stop harmful plaque from forming while keeping the good bacteria in your mouth healthy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11125740

• Investigating how certain bacteria contribute to tooth decay in young children

  This study is looking at how a certain bacteria called Streptococcus mutans might be making tooth decay worse in young kids under six, and it aims to find new ways to help prevent cavities in children who are at higher risk.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11092008

• Exploring how childhood trauma affects dental health in children

  This study is looking at how tough experiences in childhood might affect kids' dental health, especially for those from minority backgrounds, by exploring how the brain and gut bacteria work together to influence tooth decay.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11057403

• Understanding how genes affect tooth development and cavity risk

  This study is looking at how certain genes, especially one called TRPS1, might affect how children's teeth develop and their chances of getting cavities, with the hope of finding ways to help prevent tooth decay based on each child's unique genetic makeup.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11038662

• Understanding how different parts of dental care interventions affect children's oral health

  This study is looking at how different parts of dental care for kids aged 0-11 work together to keep their smiles healthy, so we can find the best ways to help them have great oral health.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10949695

• Reducing sugar consumption to prevent dental issues

  This study is all about helping dentists share tips and strategies to encourage everyone to cut down on sugar for better dental health and overall well-being.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10913311

• Targeting harmful bacteria to prevent tooth decay

  This study is looking for new ways to stop cavities by targeting the bad bacteria in your mouth that thrive on sugary foods, so you can enjoy better oral health and fewer trips to the dentist!

  NIH research Ada Forsyth Institute, INC. · Cambridge, United States · NIH-10897226

• Evaluating the effects of fluoridated bottled water on dental health in children

  This study is looking at whether drinking fluoridated bottled water can help prevent cavities in kids who live in places without fluoridated tap water, and it involves about 470 babies from Kinston, NC.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10897119

• Using a new type of plasma to prevent dental cavities

  This study is exploring a new way to help prevent cavities by using a special technique that delivers fluoride more effectively to strengthen your teeth, so you can enjoy better dental health and fewer cavities.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10892292

• Understanding how buprenorphine affects dental health in patients with opioid use disorders

  This study is looking at how buprenorphine, a medication for opioid use disorder, affects dental health, especially since some patients have reported dental problems while using it, and the goal is to find ways to help improve their oral health.

  NIH research University of Houston · Houston, United States · NIH-10765181

• Increasing dental sealants for adolescents to improve oral health

  This study is looking at how putting more dental sealants on kids' back teeth can help prevent cavities and improve their oral health, especially for middle school students from low-income families.

  NIH research Kennesaw State University · Kennesaw, United States · NIH-10706531

• The relationship between oral bacteria and tooth decay in children with HIV

  This study looks at how the germs in the mouths of children with HIV might affect their risk of getting cavities, and it aims to find ways to help keep their teeth healthy.

  NIH research Clemson University · Clemson, United States · NIH-10424444

Related topics

Quick answers

How many Dental Caries clinical trials are recruiting right now?

37, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (8 trials), Turkey (Türkiye) (7 trials), Egypt (4 trials), France (2 trials), Belgium (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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