Vitamin D and the body's anti-inflammatory response in gum disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates the anti-inflammatory effects of vitamin D supplementation in individuals with periodontal diseases, including gingivitis and periodontitis, who are vitamin D deficient. Researchers will measure inflammatory and bone-related biomarkers in serum and periodontal tissue to see if vitamin D changes these markers when combined with non-surgical periodontal treatment and oral health education. The trial will enroll about 120 systemically healthy participants and randomize them to receive vitamin D alongside standard periodontal care or standard care alone. Outcomes focus on inflammatory pathways and bone metabolism markers to understand vitamin D’s potential role in periodontal health. The study aims to clarify whether correcting vitamin D deficiency helps reduce gum inflammation and supports periodontal treatment outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Study groups will be formed according to the 2017 Periodontal Disease Classification. Accordingly:
* Periodontally healthy; absence of bleeding on probing, erythema, edema, patient symptoms, attachment, and bone loss
* Gingivitis; patients with an average gingival index ≥0.5 according to Löe and Silness
* Stage I-II periodontitis; patients with CAL 1-2 or 3-4 mm and a maximum PPD ≤5 mm, showing radiographic horizontal bone loss up to the coronal third of the root (15%-33%), but without tooth loss due to periodontitis
* Stage III-IV periodontitis; Stage 3 and 4 patients with ≥15 teeth in their mouth, with CAL ≥5 and PPD ≥6 in at least 6 areas, and radiographic bone loss extending to the middle or apical third of the root.

Exclusion Criteria:

* Individuals who have undergone periodontal treatment in the last 6 months, have systemic diseases (such as diabetes, parathyroid and thyroid-related endocrine diseases) that may affect periodontal status, patients with chronic liver disease, hypoparathyroidism and renal failure, those who have been using medications that may affect periodontal response (aspirin, non-steroidal anti-inflammatory drugs or steroids) for a long time, those who are using additional vitamin D or calcium supplements in the pre-study phase, those who are pregnant or breastfeeding, and those with hypercalcemia and malabsorption syndrome will not be included in the study.

Where it's running

• Recep Tayyip Erdoğan University
  Rize, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Hatice Yemenoglu
• Email: htcymnglu@hotmail.com
• Phone: +905052977517

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.