Keeping gums healthy after periodontal treatment with sodium bicarbonate toothpaste

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

About 100 adults attending the University of Plymouth dental education facilities who have completed non-surgical periodontal treatment will be enrolled. Participants will be assigned to use either a sodium bicarbonate fluoride toothpaste or a placebo toothpaste while receiving standardized oral hygiene instruction and periodontal maintenance over six months. Clinical measures (plaque scores, gingival bleeding, periodontal pocket depths), salivary biochemical markers, and the oral microbiome will be recorded at baseline, 3 months, and 6 months. Dental care includes an initial examination, three confirmed hygienist visits, and additional dental appointments as needed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult participants \>18 years, of any gender will be recruited.

Exclusion Criteria:

* Full dentures
* Diabetics
* Cancer diagnosis
* Pregnancy
* Use of antibiotics (\<3 months prior to participation)
* Use of antibacterial mouthwash
* Inorganic nitrates taken less than 4 weeks before the study
* Immunosuppressants taken less than 4 weeks before the study
* BPE's score of less than 3, and or/ BPE score of more than two 4's.

Where it's running

• Derriford Dental Education Facility
  Plymouth, United Kingdom Recruiting

Study contacts

• Principal investigator: Zoe Brookes, BDS, MJDF, PCHE, SFHEA, PhD — University of Plymouth
• Study coordinator: Zoe Brookes, BDS, MJDF, PCHE, SFHEA, PhD
• Email: zoe.brookes@plymouth.ac.uk
• Phone: 01752 586828

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effect of Periodontal Therapy on Gut Microbes and Inflammation in People with Inflammatory Bowel Disease

  This study tests whether treating gum disease in people with inflammatory bowel disease can influence the gut microbiome and markers of systemic inflammation.

  Recruiting University of Turin, Italy · Turin, Turin · NCT07905859

• Bacterial Diversity in Gum Health With Fixed vs Removable Retainers After Braces

  This study tests the gum microbiome and gum health in adults after braces, comparing fixed lingual retainers to removable Essix retainers.

  Recruiting Universidad de Murcia · Murcia · NCT07718061

• Hyperuricemia and gum disease: is uric acid linked to bone loss in periodontitis?

  This observational study tests whether high uric acid levels are related to periodontitis and alveolar bone loss in adults.

  Recruiting Recep Tayyip Erdogan University Training and Research Hospital · Rize · NCT07666126

• See if periodontal treatment improves chewing ability and oral quality of life

  This study tests whether treating periodontitis improves how well people can chew and how they feel about their oral health.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07651579

• Vitamin D and the body's anti-inflammatory response in gum disease

  This study tests whether vitamin D can modulate the body's anti-inflammatory response in people with gum disease.

  Recruiting Recep Tayyip Erdogan University Training and Research Hospital · Rize · NCT07636733

• Candida albicans and periodontitis in Syrian patients

  This project will test whether Candida albicans is commonly present in the gum pockets of Syrian adults with chronic periodontitis.

  Recruiting Al-Hawash Private University · Homs · NCT07574827

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.