Markers of Bone Destruction and Oxidative Stress in Peri-implantitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will compare biomarkers of bone resorption (RANKL, OPG), oxidative stress (nitrotyrosine, NQO1), and a pro-inflammatory cytokine (IL-1β) in saliva and peri-implant sulcular fluid across four groups: peri-implantitis, periodontitis, and healthy peri-implant and periodontal sites. Participants will be 18–65 years old and categorized based on clinical and radiographic criteria. Samples will be collected under standardized conditions, with clinical parameters (PI, GI, BOP, PD, CAL) recorded at six sites per tooth or implant. Analyses will aim to determine the diagnostic value of these biomarkers for early detection and progression of peri-implant diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Systemically healthy volunteers aged 18-65. For Peri-implantitis group: Implants in function for ≥1 year, radiographic bone loss ≥ 2 mm, probing depth (PD) ≥ 5 mm, and presence of bleeding on probing (BOP) or suppuration.

For Periodontitis group: At least one tooth with PD ≥ 4 mm, presence of BOP, and radiographic bone loss.For Healthy groups: PD ≤ 3 mm, no clinical inflammation (BOP-), and no radiographic bone loss.

(According to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases) -

Exclusion Criteria:Presence of systemic diseases (e.g., diabetes, rheumatoid arthritis, osteoporosis).

Use of antibiotics, anti-inflammatory, or immunosuppressive drugs within the last 3 months.

Pregnancy or breastfeeding.

Smoking (current smokers).

History of periodontal or peri-implant surgical treatment within the last 6 months.

Implant failure (mobility).

Signs of acute infection (fever, systemic symptoms).

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Where it's running

• Gülhane Faculty of Dentistry, University of Health Sciences
  Keçiören, Ankara, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Gülbahar Ustaoğlu, Professor — University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology
• Study coordinator: Nurullah Yurdakul, Dr.
• Email: nurullah.yurdakul@sbu.edu.tr
• Phone: +905340757662

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.