Oral bacteria, gum disease, and oral HPV in people living with HIV
Official title: Oral microbiome and periodontal diseases in oral HPV infection among people living with HIV
Funded at Emory University · NIH-11384763 · Data updated 2026-11-12
This project looks at how the mouth’s bacteria and gum disease relate to oral HPV in people with HIV, and what immune factors might be involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 11, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $780,433 |
| NIH project number | 5R01DE032243-05 |
| Project ID | NIH-11384763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV who may have or be at risk for oral HPV infection and related oral health issues.
✕Less likely to help
People without HIV or without oral HPV infection risk may not directly benefit from this study.
What this research studies
If you have HIV, understanding which mouth bacteria and gum problems might be linked to oral HPV could help explain why HPV-related mouth cancers occur more often in this group. The study will examine the mouth’s microbial communities and immune responses to find clues about HPV infection and persistence. Researchers will collect samples from participants and analyze how bacteria, gum disease, and immune signals interact. The goal is to identify potential targets for prevention or early intervention in people living with HIV.
Why it matters
Potential benefit: If successful, the findings could inform new strategies to prevent or reduce oral HPV infection and HPV-related cancers in people with HIV.
How similar studies have gone: Prior work shows links between the oral microbiome, periodontal disease, and infections, but studies in HIV populations are limited and findings may be exploratory.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Xiao, Canhua — Emory University
- Study coordinator: Xiao, Canhua
Related research
Other NIH-funded projects on the same topics.
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Mouth bacteria, gum disease, and oral HPV in people living with HIV
This project looks at whether mouth bacteria and gum disease are linked to getting or keeping oral HPV in people living with HIV.
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The connection between oral bacteria, gum disease, and HPV infection in people with HIV
This study is looking at how the bacteria in your mouth and gum diseases might affect HPV infections in people living with HIV, and it wants to learn how social factors play a role in this, so we can better understand why HPV-related cancers are more common in this group.
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Epigenetics of oral HPV-related mouth and throat cancer in people with HIV in Nigeria
This project looks for DNA markers in people living with HIV in Nigeria to find who has or might develop HPV-related mouth and throat cancers.
-
Antibodies and vaginal bacteria in HPV-related cervical changes
This project looks at whether antibodies bind different vaginal bacteria in women with HPV or cervical cell changes to understand why some women develop more serious lesions.
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How HIV Treatment Might Change Oral HPV Risk
A study explored how antiretroviral therapy for HIV could affect the mouth’s lining and the chance of catching oral HPV, with participants including people living with HIV on ART and people using ART for PrEP.
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Understanding how the penile cancer microbiome and p16 relate to HPV and outcomes across diverse patients
This project will look at how the tiny microbes living in penile tumors, p16 protein levels, high-risk HPV, and clinical outcomes are connected across patients from different regions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.