Filling intrabony periodontal defects with a volume-stable collagen matrix versus bovine bone mineral with 10% collagen
Official title: Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen. A 12-month Multi-center Randomized Controlled Trial
Run by University of Bern · NCT06676826 · Data updated 2026-11-12
This trial will test whether a volume-stable collagen matrix or a deproteinized bovine bone graft with 10% collagen better helps adults with advanced periodontitis heal their intrabony defects.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of Bern Academic / other |
| Locations | 1 site (Bern) |
| Status | Recruiting |
| Started | September 1, 2025 |
| Main results expected | September 30, 2026 |
| Study ends | December 30, 2027 |
| Registry record updated | October 6, 2025 |
| Trial ID | NCT06676826 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) with Stage III–IV periodontitis who have a single-aspect intrabony defect ≥3 mm, probing depth ≥6 mm, at least 2 mm of keratinized tissue, and no systemic conditions that impair healing are ideal candidates.
✕Probably not a fit
Patients with systemic diseases that affect wound healing, heavy smokers (>10 cigarettes/day), poor oral hygiene after therapy, pregnant or lactating women, multi-rooted teeth with furcation involvement, circumferential defects, interdental craters, or third molars are unlikely to be eligible or to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional comparison treats intrabony periodontal defects by open flap debridement followed by filling the defect with either a volume-stable collagen matrix (VCMX) or deproteinized bovine bone mineral containing 10% collagen. Eligible participants are adults with Stage III–IV periodontitis who have single-aspect intrabony defects ≥3 mm and probing depths ≥6 mm. Surgical treatment is performed at the University of Bern and clinical healing and regenerative outcomes will be recorded and compared between the two graft materials. The study aims to clarify whether VCMX can serve as an alternative to bovine-derived grafts in regenerative periodontal surgery.
Why it matters
Potential benefit: If successful, a volume-stable collagen matrix could offer a synthetic graft option that improves bone fill and periodontal attachment while reducing reliance on animal-derived materials.
How similar studies have gone: Deproteinized bovine bone mineral with collagen has established positive clinical results in periodontal regeneration, while volume-stable collagen matrices are less extensively studied but have shown encouraging early outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Patients with localized or generalized periodontitis Stage III and Stage IV, Grade A-B-C * Males and females * Age at least 18 years and older * Presence of interdental intra-bony defects (I, II and III walls) in either the maxilla or the mandible with a PD ≥ 6 mm * Defects with an intra-bony component \> 3 mm for both groups * Intra-bony defect located only at one aspect (mesial or distal) * Presence of at least 2 mm of keratinized soft tissue. Exclusion Criteria * Patients with systemic disease that could interfere with periodontal wound healing * Prolonged antibiotic treatment or anti-inflammatory treatment within 4 weeks prior to surgery * Pregnant or lactating * Smokers with \> 10 cig./day * Patients with FMPS and FMBS \> 25 % after completion of non-surgical periodontal therapy * Multi-rooted teeth with furcation involvement * Third molars * Teeth with circumferential defects * Interdental craters * Written Informed Consent
Where it's running
-
University of Bern
Bern, Switzerland Recruiting
Study contacts
- Study coordinator: Alexandra Stähli, MD
- Email: alexandra.staehli@unibe.ch
- Phone: +41316840600
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.