Pain relief for knee osteoarthritis: a 2nd phase study of LY4065967 vs placebo

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 2 interventional trial as part of a broader chronic pain master protocol. Participants have chronic knee pain due to osteoarthritis with radiographic confirmation and meet defined health criteria, including BMI and blood sugar controls. The study compares LY4065967 to placebo, assessing safety and efficacy over a set period. Enrollment takes place at several U.S. sites, with ongoing monitoring for knee-specific outcomes and overall health. The protocol aims to accelerate development of new treatments for chronic pain by using a standardized testing framework.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have presence of index knee pain for more than 12 weeks at screening
* Have an x-ray supporting diagnosis of osteoarthritis according to the American College of Rheumatology with a Kellgren-Lawrence grade 2 to 4 radiographic classification of index knee
* Have a body mass index ≤40 kilograms per meter squared (kg/m²) (inclusive)
* Have stable glycemic control as indicated by a glycated hemoglobin (HbA1c) less than or equal to 10 at time of screening

Exclusion Criteria:

* Are pregnant or breastfeeding
* Have had a surgical procedure or therapeutic injection in the affected knee within 3 months prior to screening
* Have presence of surgical hardware or other foreign body in the index knee
* Have ongoing complex regional pain syndrome or other concurrent medical condition that could interfere with the evaluation of pain in the index knee.
* Have had any joint replacement of the lower extremity, such as hip, knee or ankle, in the 6 months prior to screening
* Have an abnormal blood pressure (BP) (systolic BP greater than 140 millimeters mercury (\>140 mm Hg) and diastolic BP\>90 mm Hg) at screening
* Have history or current clinically significant cardiac disease, including arrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, or any other conditions that could predispose to arrhythmia in the judgement of the investigator

Where it's running

• Central Research Associates
  Birmingham, Alabama, United States Recruiting
• Synexus Clinical Research US, Inc.
  Phoenix, Arizona, United States Recruiting
• Arizona Research Center
  Phoenix, Arizona, United States Recruiting
• Desert Oasis Healthcare Medical Group
  Palm Springs, California, United States Recruiting
• Artemis Institute for Clinical Research
  Riverside, California, United States Recruiting
• Artemis Institute for Clinical Research
  San Diego, California, United States Recruiting

Study contacts

• Study coordinator: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
• Email: LillyTrials@Lilly.com
• Phone: 1-317-615-4559

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• National Registry for Artery Embolization to Treat Chronic Pain

  This study is testing if a procedure that blocks blood flow to painful areas can help people with chronic pain from osteoarthritis and other conditions feel better.

  Recruiting at 2 sites Vascular Solutions of North Carolina · Cary, North Carolina and 1 other locations · NCT06477965

• Helping osteoarthritis patients walk with NSAIDs

  This study is testing a new program that combines special exercises and occasional use of pain relief medications to help people with hip or knee osteoarthritis walk better.

  Recruiting Phase 4 University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT05761015

• Cognitive Rehabilitation of Everyday Goals With GMT: How Different Ways of Delivery Work

  This study tests Goal Management Training to see if a Swedish version helps adults with acquired brain injury or chronic pain improve practical goal-directed thinking and daily functioning.

  Recruiting at 2 sites Karolinska Institutet · Luleå, Norrbotten County and 2 other locations · NCT07924774

• One-time Pain Reprocessing Therapy session for chronic pain at The Ottawa Hospital

  A single four-hour session of Pain Reprocessing Therapy is being tested to see if it can help adults with chronic pain feel better and have less pain.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07919626

• Meaning-Based Psychotherapy for Adults with Chronic Pain

  This trial tests whether Meaning-Based Psychotherapy helps adults with chronic pain feel more purposeful, feel less depressed, and have a better quality of life compared with optimized usual care therapy.

  Recruiting Hospital Clinico Universitario San Cecilio · Granada, Granada · NCT07915440

• SVF cellular mix, secretome, and knee response in osteoarthritis

  This study tests the cellular composition and secretome of research-only adipose-derived SVF in adults with knee OA who are already planned to receive an autologous SVF injection as part of their care.

  Recruiting Yonsei University · Seoul · NCT07898501

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.