Effect of a Resistance Exercise Program on IGF-1 Levels in Knee Osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center study examines whether eight weeks of resistance training alter serum IGF-1 and whether those changes relate to improvements in pain and function, as well as radiographic features. Participants include adults aged 40–75 with Kellgren-Lawrence grade 2–3 knee OA, some with metabolic syndrome characteristics. Researchers will compare pre- and post-intervention IGF-1, clinical scores (WOMAC, VAS), and MOAKS osteophyte scores to explore potential associations and the modifying effect of the metabolic phenotype. The trial is non-randomized and non-blinded, with participants allocated into two predefined groups based on phenotype. The lead site is in Istanbul, Turkey, at Sisli Hamidiye Etfal Training and Research Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) clinical and radiographic criteria.
* Radiological severity of Kellgren-Lawrence (KL) grade 2 or 3 on standing anteroposterior knee radiographs
* Having a knee magnetic resonance imaging (MRI) scan obtained within the past 1 year
* Age between 40 and 75 years
* Volunteering to participate in the study and signing the informed consent form

Exclusion Criteria:

* Receiving intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) in the affected knee within the last 6 months
* History of previous major knee surgery, knee arthroplasty, or lower extremity trauma affecting biomechanics
* Diagnosis of rheumatoid arthritis, or other inflammatory joint diseases
* Presence of severe cardiovascular, neurological, or musculoskeletal disorders that would contraindicate or prevent participation in a structured resistance exercise program
* History of malignancy or presence of active malignancy
* Presence of active infection
* Cognitive impairment or inability to understand and follow the exercise instructions and questionnaires

Where it's running

• Sisli Hamidiye Etfal Training and Research Hospital
  Istanbul, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Kadriye Banu Kuran, MD, Prof. — Sisli Hamidiye Etfal Training and Research Hospital
• Study coordinator: Bora Şahin, MD, PMR resident physician
• Email: borashn55@gmail.com
• Phone: +905386673139

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.