Helping osteoarthritis patients walk with NSAIDs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to improve walking ability in patients with painful hip or knee osteoarthritis through a multimodal rehabilitation program combined with intermittent use of nonsteroidal anti-inflammatory drugs (NSAIDs). The study involves a single-center, non-randomized, open-label design where participants will undergo assessments and interventions over a 12-week period. Patients will receive tailored footwear, education on managing pain and side effects, and will track their pain and activity levels throughout the study. The goal is to optimize pain relief while minimizing the risks associated with continuous NSAID use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Uni- or bilateral hip or knee idiopathic osteoarthrosis (ACR criteria, Kellgren-Lawrence grade 2 or more on recent X-ray), responsible for pain since 3 at least months, and pain at walking which intensity is at least 4/10 on a numerical rating scale.
* Less than 3 relevant walks (at least 20 minutes or 1000 km) a week.
* Ability to understand and to follow the protocol, and to answer the questionnaires

Exclusion Criteria:

* Pregnancy or breastfeeding
* Legal protection
* Body weight \< 40 kg or underweight
* Body weight \>120 kg or obesity
* Unability to walk, or unability to walk without support devices (sticks, crutches, orthoses and knee pads are allowed)
* Secondary osteoarthrosis (rheumatism, septic arthritis, recent osteonecrosis, hemochromatosis, gout, acromegalia…).
* Concomitant general bone disease (Paget, Reiter…).
* Concomitant and relevant painful disease else than due to osteoarthrosis (e.g. neuropathic pain, fibromyalgia…)
* Previous recent intervention (e.g. surgery, arthroscopy, joint infiltration) expected to relief osteoarthrosis pain throughout the study period.
* Planned intervention similar to those abovementioned, during the study period.
* Recent initiation of any new analgesic treatment (including systemic steroids).
* Planned initiation of any program expected to relief osteoarthrosis pain during the study period, such as physiotherapy, cognitive behavioral therapy…).
* Planned major surgery during the study period.
* Current cancer disease.
* Immunosuppression.
* Autoimmune disease.
* Concomitant topical or systemic NSAID treatment.
* Chronic strong opioid intake.
* Concomitant insulin therapy.
* Any absolute or relevant contraindication to NSAIDs or acetaminophen, according to the French drug agency

Where it's running

• CHU Clemront-Ferrand
  Clermont-Ferrand, France Recruiting

Study contacts

• Study coordinator: Lise Laclautre
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: 04 73 75 11 95

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.