Using CBD to treat knee osteoarthritis pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the safety and efficacy of cannabidiol (CBD) as a treatment for knee osteoarthritis (KOA), a condition that causes significant pain and functional limitations in adults. Participants with a clinical diagnosis of KOA and moderate to severe knee pain will receive either CBD extract or a placebo. The study aims to assess the pain-relieving effects of CBD, which may provide an alternative to traditional pain medications like NSAIDs that carry health risks. The trial will also evaluate the tolerability and acceptability of CBD in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. established clinical diagnosis of knee osteoarthritis (KOA)
2. moderate to severe knee pain (≥4/10) with physical activity in one or both knees

Exclusion Criteria:

1. pregnant (urine pregnancy test) or lactating
2. current cannabis (THC and/or CBD) use (urine drug screen)
3. any prior or ongoing medical condition that, in the investigators' opinion, could adversely affect the safety of the subject
4. any major surgery within 3 months prior to recruitment or planned orthopedic surgery for any time during this study which would interfere with the ability to report pain or quality of life outcome measures
5. any exposure to another investigational drug within 3 months prior to screening
6. BMI ≥ 45
7. current use of any enzyme-modifying drugs, including strong inhibitors or strong inducers of cytochrome P (CYP) enzymes
8. history of:

   1. suicidal ideation or self-harm behavior
   2. seizure disorder or traumatic brain injury,
   3. liver or kidney disease, and
   4. cardiovascular diseases

Where it's running

• Sports Medicine Research Laboratory
  Gainesville, Florida, United States Recruiting

Study contacts

• Study coordinator: Paul A. Borsa, PhD
• Email: pborsa@ufl.edu
• Phone: 352-294-1726

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.