Using CBD to treat knee osteoarthritis pain
Sub-Lingual Administration of Cannabidiol for Knee Osteoarthritis
This study is testing if CBD can help relieve knee pain for adults with osteoarthritis who are struggling with moderate to severe discomfort.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 40 Years to 75 Years |
| Sex | All |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Trial ID | NCT06414473 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the safety and efficacy of cannabidiol (CBD) as a treatment for knee osteoarthritis (KOA), a condition that causes significant pain and functional limitations in adults. Participants with a clinical diagnosis of KOA and moderate to severe knee pain will receive either CBD extract or a placebo. The study aims to assess the pain-relieving effects of CBD, which may provide an alternative to traditional pain medications like NSAIDs that carry health risks. The trial will also evaluate the tolerability and acceptability of CBD in this patient population.
Who should consider this trial
Good fit: Ideal candidates are adults with a clinical diagnosis of knee osteoarthritis and moderate to severe knee pain during physical activity.
Not a fit: Patients who are currently using cannabis products or have certain medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer a safer, non-pharmacological option for managing knee osteoarthritis pain.
How similar studies have performed: While there is limited data on CBD for knee osteoarthritis specifically, preliminary studies suggest potential benefits of cannabinoids for pain relief in various conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. established clinical diagnosis of knee osteoarthritis (KOA) 2. moderate to severe knee pain (≥4/10) with physical activity in one or both knees Exclusion Criteria: 1. pregnant (urine pregnancy test) or lactating 2. current cannabis (THC and/or CBD) use (urine drug screen) 3. any prior or ongoing medical condition that, in the investigators' opinion, could adversely affect the safety of the subject 4. any major surgery within 3 months prior to recruitment or planned orthopedic surgery for any time during this study which would interfere with the ability to report pain or quality of life outcome measures 5. any exposure to another investigational drug within 3 months prior to screening 6. BMI ≥ 45 7. current use of any enzyme-modifying drugs, including strong inhibitors or strong inducers of cytochrome P (CYP) enzymes 8. history of: 1. suicidal ideation or self-harm behavior 2. seizure disorder or traumatic brain injury, 3. liver or kidney disease, and 4. cardiovascular diseases
Where this trial is running
Gainesville, Florida
- Sports Medicine Research Laboratory — Gainesville, Florida, United States (Recruiting)
Study contacts
- Study coordinator: Paul A. Borsa, PhD
- Email: pborsa@ufl.edu
- Phone: 352-294-1726
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.