Comparing barbed and conventional wound closure after hip or knee replacement
Evaluation of Different Suture Materials and Closure Techniques in Lower Extremity Arthroplasty: Effects on Wound Healing, Functional Outcomes, and Complications
This study will test whether barbed sutures or conventional sutures lead to better wound healing and fewer complications for adults having primary or aseptic revision hip or knee replacement.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 30 Years and up |
| Sex | All |
| Sponsor | Umraniye Education and Research Hospital Government |
| Locations | 1 site (Istanbul, Istanbul) |
| Trial ID | NCT07439575 on ClinicalTrials.gov |
What this trial studies
This is a prospective, randomized 1:1 trial enrolling at least 90 adults undergoing primary or aseptic revision total hip or knee arthroplasty to compare two wound closure strategies that differ in suture material and technique. All operations will be performed by the same surgical team using standardized perioperative protocols to limit confounding. Primary outcomes are wound-related complications (prolonged drainage, dehiscence, surgical site infection, and local inflammation) within 90 days; secondary outcomes include operative time, intraoperative blood loss, cosmetic appearance, and functional scores. Patients will be followed postoperatively to capture wound healing, complications, and functional recovery data.
Who should consider this trial
Good fit: Adults aged 30 or older undergoing primary or aseptic revision total hip or total knee arthroplasty who can provide informed consent and can have surgery and follow-up with the designated surgical team are ideal candidates.
Not a fit: Patients under 30, those on immunosuppressive therapy, with complicated diabetes, chronic venous insufficiency, peripheral arterial disease, arthroplasty for malignancy, or active/previous surgical site infection are excluded and unlikely to benefit from the results.
Why it matters
Potential benefit: If successful, the trial could identify a closure method that reduces wound complications and improves recovery after hip and knee replacement.
How similar studies have performed: Previous trials comparing barbed versus conventional sutures have often shown faster closure times and mixed effects on wound complication rates, so this study builds on but does not definitively resolve existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 30 years * Patients undergoing primary total hip arthroplasty or total knee arthroplasty * Patients undergoing aseptic revision total hip or knee arthroplasty * Surgery performed by the same surgical team * Ability to provide informed consent Exclusion Criteria: * Age \< 30 years * Patients receiving immunosuppressive therapy * Patients with complicated diabetes mellitus * Chronic venous insufficiency * Peripheral arterial disease * Arthroplasty performed due to malignancy * Active or previous surgical site infection
Where this trial is running
Istanbul, Istanbul
- Umraniye Training and Research Hospital — Istanbul, Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Bahattin Kemah, MD — Umraniye Education and Research Hospital
- Study coordinator: Bahattin Kemah, MD
- Email: bahattinkemah.md@gmail.com
- Phone: +905337198121
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.