Comparing barbed and conventional wound closure after hip or knee replacement
Official title: Evaluation of Different Suture Materials and Closure Techniques in Lower Extremity Arthroplasty: Effects on Wound Healing, Functional Outcomes, and Complications
Run by Umraniye Education and Research Hospital · NCT07439575 · Data updated 2026-11-12
This study will test whether barbed sutures or conventional sutures lead to better wound healing and fewer complications for adults having primary or aseptic revision hip or knee replacement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years and up |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Umraniye Education and Research Hospital Government |
| Locations | 1 site (Istanbul, Istanbul) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | August 2026 |
| Study ends | August 2026 |
| Registry record updated | March 2, 2026 |
| Trial ID | NCT07439575 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 30 or older undergoing primary or aseptic revision total hip or total knee arthroplasty who can provide informed consent and can have surgery and follow-up with the designated surgical team are ideal candidates.
✕Probably not a fit
Patients under 30, those on immunosuppressive therapy, with complicated diabetes, chronic venous insufficiency, peripheral arterial disease, arthroplasty for malignancy, or active/previous surgical site infection are excluded and unlikely to benefit from the results.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized 1:1 trial enrolling at least 90 adults undergoing primary or aseptic revision total hip or knee arthroplasty to compare two wound closure strategies that differ in suture material and technique. All operations will be performed by the same surgical team using standardized perioperative protocols to limit confounding. Primary outcomes are wound-related complications (prolonged drainage, dehiscence, surgical site infection, and local inflammation) within 90 days; secondary outcomes include operative time, intraoperative blood loss, cosmetic appearance, and functional scores. Patients will be followed postoperatively to capture wound healing, complications, and functional recovery data.
Why it matters
Potential benefit: If successful, the trial could identify a closure method that reduces wound complications and improves recovery after hip and knee replacement.
How similar studies have gone: Previous trials comparing barbed versus conventional sutures have often shown faster closure times and mixed effects on wound complication rates, so this study builds on but does not definitively resolve existing evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 30 years * Patients undergoing primary total hip arthroplasty or total knee arthroplasty * Patients undergoing aseptic revision total hip or knee arthroplasty * Surgery performed by the same surgical team * Ability to provide informed consent Exclusion Criteria: * Age \< 30 years * Patients receiving immunosuppressive therapy * Patients with complicated diabetes mellitus * Chronic venous insufficiency * Peripheral arterial disease * Arthroplasty performed due to malignancy * Active or previous surgical site infection
Where it's running
-
Umraniye Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Bahattin Kemah, MD — Umraniye Education and Research Hospital
- Study coordinator: Bahattin Kemah, MD
- Email: bahattinkemah.md@gmail.com
- Phone: +905337198121
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.