Gut bacteria and knee implants: comparing people with well-functioning vs. revision total knee replacements
Official title: Gut Microbiome in Orthopaedics: Investigating the Role of Gut Microbiome Composition in Total Knee Arthroplasty Failure
Run by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · NCT06951477 · Data updated 2026-11-12
This study tests whether the gut microbiome differs between people with a knee replacement that works well and those who need a revision surgery.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Academic / other |
| Locations | 1 site (London, Ontario) |
| Status | Recruiting |
| Started | August 21, 2025 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | September 22, 2026 |
| Trial ID | NCT06951477 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for revision total knee arthroplasty and willing to provide consent and follow-up data.
✕Probably not a fit
Patients without the identified microbiome patterns or who do not undergo revision may not see a direct benefit from this observational study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will compare the gut microbiome of patients scheduled for revision total knee arthroplasty with that of people who have well-functioning knee replacements. Researchers will analyze gut bacteria and related markers to see if there are differences that could relate to infection or implant loosening. The study will consider antibiotic use and immune or bone-regulation factors that may be influenced by gut microbes. Data will come from stool samples and clinical information collected during routine care, without assigning any treatment. The aim is to identify microbiome patterns associated with revision knee outcomes.
Why it matters
Potential benefit: If successful, findings could pave the way for microbiome-informed strategies to reduce complications after knee replacement.
How similar studies have gone: Previous research in other surgical areas suggests the gut microbiome can influence infection risk and recovery, but this specific association in revision knee arthroplasty is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Scheduled to undergo a revision TKA * Willing and able to comply with follow-up requirements * Ability to provide informed consent * Ability to read, write, and speak English Exclusion Criteria: * Pregnancy * Less than 3 months post-operation from primary surgery * Diagnosis of periprosthetic fracture * Scheduled for DAIR (debridement, antibiotics, and implant retention) revision surgery * Scheduled for stage 2 PJI revision
Where it's running
-
University Hospital
London, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Brent Lanting, MD, MSc, FRCSC — Schulich School of Medicine & Dentistry
- Study coordinator: Brent Lanting, MD, MSc, FRCSC
- Email: Brent.Lanting@lhsc.on.ca
- Phone: 519-685-8500
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.