Condition

Anterior Cruciate Ligament Injuries clinical trials and research

• 33Clinical trials
• 14Countries

Newest Anterior Cruciate Ligament Injuries clinical trials

All recruiting trials (33)

• Perturbation Training vs Functional Activities after ACL Reconstruction

  This study tests whether perturbation training or task-oriented functional activities help people 18–45 with ACL reconstruction recover better than standard rehab.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07642752

• Tracking recovery after arthroscopic shoulder and knee surgeries

  This will follow people having routine arthroscopic shoulder or knee surgery to see if patient characteristics, tear details, or surgical choices predict better recovery and function over two years.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07501013

• Magic Angle Direction Imaging for ACL tears and meniscus injuries

  This study tries a new low-field MRI technique called Magic Angle Direction Imaging to see if it shows ACL tears and meniscus injuries more clearly in adults scheduled for ligament repair.

  Recruiting at 2 sites Imperial College London · London and 1 other locations · NCT07366619

• Proprioceptive exercises to aid recovery after ACL surgery

  This trial will see if adding proprioceptive exercises to standard balance training helps people aged 20–40 during the early rehab period after ACL surgery.

  Recruiting Uskudar University · Sanliurfa · NCT07333092

• Visual-guided balance training to improve knee function after ACL reconstruction

  This program tests whether adding visual-guided balance training to standard rehabilitation helps adults 18–45 recover knee function and walking after ACL reconstruction.

  Recruiting Peking University Third Hospital · Beijing · NCT07306221

• Predicting knee cartilage wear and pain after early osteoarthritis or a recent ACL injury

  This project will try to create computer models that predict cartilage damage and pain over time for people with early knee osteoarthritis or an ACL injury within the past year.

  Recruiting at 2 sites Aalborg University · Aalborg, North Denmark and 1 other locations · NCT07134244

• Functional knee bracing after quadriceps ACL reconstruction

  This trial will test whether wearing a functional knee brace after quadriceps-tendon ACL reconstruction helps young athletes and military personnel return to sport and reduces graft failures over two years.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06942754

• Comparing pain management methods for ACL surgery

  This study is testing whether a new way of managing pain before ACL surgery works better than a traditional method to help patients recover more comfortably.

  Recruiting Ankara University · Ankara · NCT06936995

• Assessing ACL injury risk in healthy athletes

  This study is trying to see how muscle strength and movement patterns in healthy athletes can help predict the risk of ACL injuries over a year.

  Recruiting Sanford Health · Fargo, North Dakota · NCT06635668

• Low-load blood flow restriction versus high-load eccentric training for muscle changes and knee injury prevention in young athletes

  This study tests whether low-load blood flow restriction training helps increase muscle size and lower the risk of patellofemoral pain and ACL injury more than high-load eccentric or sham training in young athletes.

  Recruiting Udayana University · Denpasar, Bali · NCT06566950

• Using intraosseous morphine to manage pain during ACL reconstruction

  This study tests if giving morphine directly into the bone can help reduce pain and the need for other pain medications in young adults having ACL surgery.

  Recruiting Phase 4 The Methodist Hospital Research Institute · Houston, Texas · NCT06511232

• Early gait training to prevent knee cartilage degeneration after ACL surgery

  This study tests if starting walking training right after ACL surgery can help prevent knee cartilage damage in patients.

  Recruiting Peking University Third Hospital · Beijing · NCT06368544

• Using a wearable electrical stimulation device to improve recovery after knee surgery in military cadets

  This study is testing if a new wearable device can help military cadets recover faster and better after knee surgery.

  Recruiting Keller Army Community Hospital · West Point, New York · NCT06341868

• Comparing single-bundle and double-bundle ACL reconstruction techniques

  This study is testing which surgical technique, single-bundle or double-bundle ACL reconstruction, works better for people with ACL injuries.

  Recruiting Chang Gung Memorial Hospital · Taoyuan, taoyuan · NCT06341192

• Using concentrated bone marrow to improve outcomes in knee surgery

  This study is testing if using concentrated bone marrow during knee surgery can help people recover better and feel less pain after having their ACL surgery redone.

  Recruiting at 2 sites Phase 4 Hospital for Special Surgery, New York · Atlanta, Georgia and 1 other locations · NCT06311513

• Promoting daily steps to prevent osteoarthritis after ACL reconstruction

  This study is testing if increasing daily steps can help protect knee cartilage and prevent osteoarthritis in people who have had ACL surgery.

  Recruiting University of Georgia · Athens, Georgia · NCT06193343

• Comparing two surgical techniques for ACL reconstruction

  This study is testing which of two surgical methods for ACL reconstruction works better for people with knee instability caused by additional ligament injuries.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06147427

• Improving recovery after ACL surgery with virtual therapy

  This study is testing if a virtual therapy program can help people recover better and get back to sports after ACL surgery compared to just regular care.

  Recruiting Henry Ford Health System · Detroit, Michigan · NCT05965310

• Graded exposure and mindfulness meditation for patients recovering from ACL reconstruction

  This study is testing if a combination of mindfulness meditation and graded exposure can help young adults who have had ACL surgery feel less anxious and improve their reaction time during recovery.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT05949177

• Gait rehabilitation using biofeedback for knee injuries

  This study is testing if real-time feedback on walking can help younger people who had knee surgery recover better and avoid early signs of osteoarthritis.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT05848622

• Using blood flow restriction training to help adolescents recover after ACL surgery

  This study is testing if combining blood flow restriction training with regular rehab helps teenagers recover better and faster after ACL surgery.

  Recruiting Connecticut Children's Medical Center · Farmington, Connecticut · NCT05754632

• Treatment for Anterior Cruciate Ligament Degeneration

  This study is testing a new surgical method to treat knee problems caused by Anterior Cruciate Ligament degeneration to see if it helps patients feel better than the usual treatments.

  Recruiting Artromedical Konrad Malinowski Clinic · Bełchatów, Łódź Voivodeship · NCT05701579

• Comparing ACL repair and reconstruction for knee injuries

  This study is testing whether a new way to fix knee ligament injuries can work as well as the standard surgery for people who hurt their ACL recently.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05584020

• Vibration therapy for knee pain after ACL surgery

  This study is testing if whole body vibration therapy can help people aged 18 to 60 recover better from knee pain after ACL surgery.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT05501210

• Comparing two types of grafts for ACL reconstruction

  This study is testing which type of graft, quadriceps tendon or bone-patellar tendon-bone, helps people recover better after ACL surgery.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05461326

• Using PRP injections to improve recovery after ACL surgery

  This study tests if PRP injections can help people recover better and reduce inflammation after ACL surgery compared to a placebo.

  Recruiting Phase 3 Hospital for Special Surgery, New York · New York, New York · NCT05412381

• Using the NXSignal Device to treat ACL injuries

  This study is testing if the NXSignal device can help people recover better from ACL injuries after surgery compared to a placebo or standard rehab.

  Recruiting University of Las Palmas de Gran Canaria · Las Palmas de Gran Canaria, Las Palmas · NCT05207943

• Using Vitamin D to Boost Quadricep Strength After ACL Injury

  This study is testing if taking Vitamin D3 can help young adults recovering from ACL surgery build stronger thigh muscles.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong · NCT05174611

• Effects of Vibration on Knee Health After ACL Surgery

  This study is testing if adding vibration therapy to regular rehab can help people recovering from ACL surgery have better knee health and lower the chance of future injuries.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina and 1 other locations · NCT04875052

• Investigating the best treatments for ACL injuries

  This study is testing whether early surgery followed by rehab or just rehab with possible later surgery works better for people with ACL injuries.

  Recruiting at 2 sites University Hospital, Akershus · Lørenskog, Akershus and 1 other locations · NCT04770233

• Comparing two types of grafts for knee ligament surgery

  This study is testing which type of graft works better for knee ligament surgery in athletes who have injured their ACL.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT04295148

• Robotic assistance for ACL reconstruction surgery

  This study tests if using a robot to help position grafts during ACL surgery can make the procedure more accurate for people with ACL injuries.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT04183803

• Preventing osteoarthritis after ACL injuries with biologic therapy

  This study is testing if a drug called anakinra can help prevent osteoarthritis in young people who have injured their ACL.

  Recruiting Early Phase 1 University of California, Los Angeles · Los Angeles, California · NCT03968913

Related topics

Quick answers

How many Anterior Cruciate Ligament Injuries clinical trials are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (14 trials), China (4 trials), Hong Kong (2 trials), France (2 trials), Turkey (Türkiye) (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 1, Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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