Examining the impact of synovectomy on pain relief after knee replacement surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of performing a synovectomy during total knee arthroplasty (TKA) for patients suffering from osteoarthritis and moderate to severe synovitis. The procedure involves removing the inflamed synovial tissue to potentially reduce post-surgical pain and improve patient satisfaction. By including 62 patients scheduled for their first unilateral TKA, the study aims to assess the short-term benefits of this intervention. The outcomes will help determine if synovectomy can lead to better pain management and overall satisfaction in patients who are likely to experience dissatisfaction after TKA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Males or females over the age of 40 diagnosed with knee osteoarthritis
2. Scheduled for first unilateral total knee arthroplasty
3. Moderate to severe (at least grade two) synovitis and synovial hyperplasia, as determined by ultrasound assessment
4. Referred to the Pre-Admission Clinic at University Hospital

Exclusion Criteria:

1. Bilateral, uni-compartmental, or revision total knee arthroplasty
2. Osteoarthritis due to genetic syndromes (e.g., Ehlers-Danlos Syndrome, etc.)
3. Known inflammatory arthropathy, another rheumatic disease, or disease-modifying anti-rheumatic drug (DMARD) use (e.g. methotrexate, hydroxychloroquine, sulfasalazine, leflunomide, TNF inhibitors, etc.) - note: Gout is NOT an exclusion
4. Joint injection (steroid or viscosupplement) within 12 weeks of Pre-Admission Clinic appointment date
5. Cannot read, write, or understand English (printed instructions are provided in English only)
6. Any factors precluding patients from attending follow-up appointments (e.g., socio-economic limitations, distance from clinic, no access to home/cell phone, etc.).
7. Cognitive impairment or psychological problems that preclude the ability to understand instructions
8. Not able to follow up at routine standard of care post-operative visits

Where it's running

• London Health Sciences Centre - University Hospital
  London, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Lyndsay E Somerville, PhD
• Email: lyndsay.somerville@lhsc.on.ca
• Phone: 5196858500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.