Can non-surgical, targeted multimodal care delay or avoid total knee replacement?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study examines whether a structured, multimodal medical management plan can extend the time before knee replacement is needed in patients with femoro-tibial osteoarthritis. Participants who have been recommended for total knee replacement will receive a combination of medical, non-medical, and previously less-used treatments, with the goal of avoiding major surgery if possible. The trial will track pain, function, and treatment pathways to identify strategies that may reduce the need for arthroplasty. It is conducted across several French centers under the leadership of Hospital Brest, with eligibility focusing on adults up to age 90 and specific imaging and clinical criteria. The aim is to clarify what constitutes a complete medical treatment plan and to personalize care based on patient situation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-90 years old
* Femoro-tibial osteoarthritis Kellgren stage stage≥ 2 without laxity in extension;
* A proposal of total knee replacement by a surgeon;
* No corticosteroid joint injection within 3 months;
* Visual analogic score pain (VAS) \>40/100 but \<90/100 or Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index function sub scale \>40/100 at inclusion;
* Wish to discuss medical care;
* Able to consent and having signed a consent form.

Exclusion Criteria:

* Contraindication or no indication to surgery or medical care (severe infection for example)
* Inflammatory arthritis
* Lack of social insurance
* Symptomatic (VAS pain \>40) contralateral knee or hip osteoarthritis (with or without replacement)
* Pregnant or breastfeeding woman
* Patient under court protection, guardianship, curatorship
* Patient deprived of liberty

Where it's running

• CHU Brest
  Brest, France Recruiting
• CHIC Quimper
  Quimper, France Recruiting
• CHU Amiens
  Amiens, France Not yet recruiting
• CHU Caen
  Caen, France Not yet recruiting
• CHD Vendée
  La Roche-sur-Yon, France Not yet recruiting
• CHU Le Mans
  Le Mans, France Not yet recruiting

Study contacts

• Principal investigator: Alain Saraux, Pr — CHU Brest
• Study coordinator: Alain Saraux, Pr
• Email: alain.saraux@chu-brest.fr
• Phone: +33 2 98 34 72 70

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.