Condition

Anterior Cruciate Ligament Rupture clinical trials and research

• 21Clinical trials
• 14Countries

Newest Anterior Cruciate Ligament Rupture clinical trials

All recruiting trials (21)

• Quadriceps tendon vs peroneus longus tendon grafts for ACL reconstruction

  This randomized trial tests whether using a quadriceps tendon autograft works as well as a peroneus longus tendon autograft for ACL reconstruction in adults, looking at knee function and donor-site effects.

  Recruiting Acibadem University · Istanbul, Besiktas · NCT07671729

• Proprioceptive exercises to aid recovery after ACL surgery

  This trial will see if adding proprioceptive exercises to standard balance training helps people aged 20–40 during the early rehab period after ACL surgery.

  Recruiting Uskudar University · Sanliurfa · NCT07333092

• All-inside versus complete tibial tunnel ACL reconstruction using hamstring grafts

  This trial will test whether the all-inside or the complete tibial tunnel surgical technique leads to better recovery in adults (18–65) having ACL reconstruction with hamstring grafts.

  Recruiting at 2 sites Universitas Indonesia · Depok and 1 other locations · NCT07023653

• Cross bracing versus early ACL reconstruction for recent ACL rupture

  This will try whether a 12-week cross bracing program plus supervised physiotherapy helps people aged 16–40 with a recent complete ACL tear more than early ACL reconstruction surgery.

  Recruiting University of Melbourne · Melbourne, Victoria · NCT06956339

• Hockey slideboard training with blood flow restriction for ACL rehabilitation

  This study is testing if combining hockey slideboard training with blood flow restriction can help people recover better and safer after ACL surgery.

  Recruiting Spitalul Municipal Odorheiu Secuiesc · Odorheiu Secuiesc, Romania · NCT06955026

• Using a robotic system to improve ACL surgery precision

  This study tests if using a robotic system during ACL surgery can make the surgery more accurate and improve recovery for patients.

  Recruiting Beijing Tsinghua Chang Gung Hospital · Beijing, Beijing Municipality · NCT06858930

• Using intraosseous morphine to manage pain during ACL reconstruction

  This study tests if giving morphine directly into the bone can help reduce pain and the need for other pain medications in young adults having ACL surgery.

  Recruiting Phase 4 The Methodist Hospital Research Institute · Houston, Texas · NCT06511232

• Comparing two methods of ACL reconstruction

  This study tests if adding a specific ligament repair during ACL surgery can help young people avoid re-injury better than the usual surgery.

  Recruiting at 2 sites Federal University of São Paulo · São Paulo, São Paulo and 1 other locations · NCT06505525

• Evaluating ACL revision surgery practices in France

  This study looks at how ACL revision surgeries are done in France to see what works best and how patients are doing afterward.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT06379308

• ACL reconstruction using a human cortical bone (Shark Screw®) versus a biocomposite interference screw

  This trial will test whether using a human cortical bone screw (Shark Screw®) instead of a biocomposite interference screw reduces tunnel widening and keeps re-rupture rates low for people having ACL reconstruction.

  Recruiting Bezirkskrankenhaus Schwaz · Schwaz, Tyrol · NCT06357091

• Evaluating return to play after ACL surgery with specific treatments

  This study is testing how different treatments after ACL surgery affect young athletes' chances of getting back to their sport.

  Recruiting Marshall University · Huntington, West Virginia · NCT06294314

• Preventing osteoarthritis after an ACL tear

  This study is testing if a 6-month online education and exercise program can help young people who have had ACL surgery prevent osteoarthritis and improve their knee health.

  Recruiting at 2 sites University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT06195423

• Evaluating ACL injury and re-rupture rates after surgery

  This study looks at how often people who had ACL surgery from 2020 to 2030 experience re-injury and how their recovery affects their ability to return to sports and quality of life.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan · NCT06194682

• ACL reconstruction using a new graft technique

  This study tests a new way to fix ACL injuries using a special graft and technique to see if it helps patients recover faster and do better than traditional methods.

  Recruiting Ankara City Hospital Bilkent · Ankara · NCT06190223

• Pre-surgery exercise to improve tendon, bone, and cartilage recovery after ACL rupture or patellar dislocation

  This program will try pre-surgery exercise rehab to see if it improves tendon healing, bone density, cartilage health, and walking in people aged 18–40 with an ACL tear or patellar dislocation.

  Recruiting Peking University Third Hospital · Beijing · NCT05924178

• Vibration therapy for knee pain after ACL surgery

  This study is testing if whole body vibration therapy can help people aged 18 to 60 recover better from knee pain after ACL surgery.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT05501210

• Optimized rehabilitation program for ACL recovery before returning to sports

  This study tests if a personalized rehab program with regular check-ins can help people recover better from ACL surgery and safely get back to sports.

  Recruiting at 3 sites Centre Hospitalier Universitaire de Saint Etienne · Challes-les-Eaux and 7 other locations · NCT05323474

• Using Vitamin D to Boost Quadricep Strength After ACL Injury

  This study is testing if taking Vitamin D3 can help young adults recovering from ACL surgery build stronger thigh muscles.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong · NCT05174611

• Follow-up on ACL reconstruction outcomes

  This study looks at how well people recover after having surgery to fix their torn ACL, to see what works best for their healing and recovery.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT04781920

• Blood flow restriction training for adolescents after ACL surgery

  This study is testing if blood flow restriction training can help teenagers recover better and get stronger after ACL surgery compared to regular rehab.

  Recruiting Children's Healthcare of Atlanta · Atlanta, Georgia · NCT04390035

• Comparing two types of grafts for knee ligament surgery

  This study is testing which type of graft works better for knee ligament surgery in athletes who have injured their ACL.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT04295148

Related topics

Quick answers

How many Anterior Cruciate Ligament Rupture clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (3 trials), Turkey (Türkiye) (3 trials), France (3 trials), Hong Kong (2 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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