Impact of an anti-inflammatory diet on knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether an anti-inflammatory diet can improve clinical outcomes in patients with knee osteoarthritis. Participants will be assigned to either an anti-inflammatory diet or a healthy diet, and the study will assess changes in disease activity, microbiome composition, and circulating metabolites. The research aims to build on previous findings that suggested dietary changes may influence osteoarthritis symptoms. By understanding the relationship between diet and osteoarthritis, the study seeks to provide evidence for dietary interventions in managing this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Unilateral radiographic symptomatic KOA
* No changes in therapy during the previous 3 months
* Interested in dietary intervention and able to provide consent and attend follow-up visits

Exclusion Criteria:

* Previous knee surgery
* Severe radiographic disease (KL grade 4)
* Rheumatoid Arthritis
* Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges)
* Use of corticosteroids and/or intra-articular injections during the preceding 3 months
* Use of fish oils and glucosamine
* Participation in a weight loss program in the preceding 6 months
* Recent changes in physical activity levels
* Regular smoking
* Patients with food allergies
* Patient with other medical conditions that will impair the ability to participate in a nutritional study
* Plan to change systemic therapy
* Patients unwilling to change dietary habits

Where it's running

• University of California
  San Diego, California, United States Recruiting

Study contacts

• Study coordinator: Monica Guma, M.D., PhD
• Email: mguma@health.ucsd.edu
• Phone: 8588226523

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.