Impact of an anti-inflammatory diet on knee osteoarthritis
An Evaluator-blinded Randomized Controlled Trial Study of the Effect of Anti-inflammatory Diet in Subjects With Osteoarthritis
This study is testing if following an anti-inflammatory diet can help people with knee osteoarthritis feel better and improve their symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, San Diego Academic / other |
| Locations | 1 site (San Diego, California) |
| Trial ID | NCT06080347 on ClinicalTrials.gov |
What this trial studies
This study investigates whether an anti-inflammatory diet can improve clinical outcomes in patients with knee osteoarthritis. Participants will be assigned to either an anti-inflammatory diet or a healthy diet, and the study will assess changes in disease activity, microbiome composition, and circulating metabolites. The research aims to build on previous findings that suggested dietary changes may influence osteoarthritis symptoms. By understanding the relationship between diet and osteoarthritis, the study seeks to provide evidence for dietary interventions in managing this condition.
Who should consider this trial
Good fit: Ideal candidates are individuals with unilateral radiographic symptomatic knee osteoarthritis who are interested in dietary changes and can commit to follow-up visits.
Not a fit: Patients with severe knee osteoarthritis, recent knee surgery, or those unwilling to change their dietary habits may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer a dietary approach to alleviate symptoms and improve quality of life for patients with knee osteoarthritis.
How similar studies have performed: Previous exploratory studies have shown promising results regarding dietary interventions in osteoarthritis, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Unilateral radiographic symptomatic KOA * No changes in therapy during the previous 3 months * Interested in dietary intervention and able to provide consent and attend follow-up visits Exclusion Criteria: * Previous knee surgery * Severe radiographic disease (KL grade 4) * Rheumatoid Arthritis * Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges) * Use of corticosteroids and/or intra-articular injections during the preceding 3 months * Use of fish oils and glucosamine * Participation in a weight loss program in the preceding 6 months * Recent changes in physical activity levels * Regular smoking * Patients with food allergies * Patient with other medical conditions that will impair the ability to participate in a nutritional study * Plan to change systemic therapy * Patients unwilling to change dietary habits
Where this trial is running
San Diego, California
- University of California — San Diego, California, United States (Recruiting)
Study contacts
- Study coordinator: Monica Guma, M.D., PhD
- Email: mguma@health.ucsd.edu
- Phone: 8588226523
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.