Serum Fetuin‑A and COMP levels in knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares serum biomarkers Fetuin‑A and COMP with clinical and radiographic severity of knee osteoarthritis. A total of 180 participants include 120 patients with Kellgren‑Lawrence grade 2–4 OA and 60 age‑ and sex‑matched healthy controls. Participants will undergo radiographs, clinical and functional assessments, and biomarker measurements to explore associations between biomarker levels and disease severity. The goal is to see if these biomarkers help reflect disease state and progression. Interventions are not used; the study is observational in design.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Diagnosis of knee osteoarthritis according to ACR (American College of Rheumatology) criteria. Knee osteoarthritis classified as Grade 2, 3, or 4 according to Kellgren-Lawrence (K-L) grading. Volunteering to participate and providing signed informed consent.

Exclusion Criteria:

* Secondary post-traumatic knee osteoarthritis, history of major knee injury or joint infection. Signs of acute joint inflammation (swelling, heat increase, erythema). History of knee surgery (open or arthroscopic). Systemic inflammatory or autoimmune diseases. History of malignancy. Advanced renal or hepatic disease. Diagnosis of Diabetes Mellitus. Current use of systemic corticosteroids. Symptomatic osteoarthritis in other major joints (hip, hand, ankle, spine). Active systemic infection (fever ≥ 38, cough, diarrhea, dysuria, leukocytosis, or elevated CRP).

Where it's running

• S.B.U. Antalya Training and Research Hospital, Department of Physical Medicine and Rehabilitation
  Antalya, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Burak Karaman, MD
• Email: burak2498@gmail.com
• Phone: +905079130762

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.