Using exosomes from stem cells to treat knee osteoarthritis
The Efficacy of Allogenic Mesenchymal Stem Cells Derived Exosomes in Osteoarthritis Patients
This study tests whether exosomes from stem cells can help people with knee osteoarthritis feel less pain and improve their knee function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 45 Years to 75 Years |
| Sex | All |
| Sponsor | Isfahan University of Medical Sciences Academic / other |
| Locations | 1 site (Isfahan) |
| Trial ID | NCT06466850 on ClinicalTrials.gov |
What this trial studies
This research investigates the therapeutic potential of exosomes derived from mesenchymal stem cells (MSCs) in patients with knee osteoarthritis. The study aims to explore how these exosomes, which carry bioactive molecules, can suppress the progression of osteoarthritis by modulating inflammatory responses and promoting cartilage health. Participants will receive exosome treatments and will be monitored for improvements in knee pain and function. The study focuses on patients with chronic knee pain and specific radiographic findings of osteoarthritis.
Who should consider this trial
Good fit: Ideal candidates are individuals with a chronic history of knee joint pain and radiographically documented osteoarthritis grades 1 to 3.
Not a fit: Patients with rheumatoid arthritis, significant joint deformities, or serious systemic diseases may not benefit from this treatment.
Why it matters
Potential benefit: If successful, this approach could provide a novel and effective treatment option for patients suffering from knee osteoarthritis.
How similar studies have performed: Other studies have shown promising results with MSC-derived therapies, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Chronic history (for at least 3 months) of knee joint pain * Body mass index (BMI) between 21.5 and 29.5 * Radiographically documented knee osteoarthritis of grades 1 to 3 (Kellgren-Lawrence (K-L) radiographic classification scale) Exclusion Criteria: * Rheumatoid arthritis and other rheumatic diseases * Varus or valgus more than 10 degrees; lateral subluxation of the patella * Deformity at the joint levels or adjacent to the knee due to fracture or any other injury * Complete rupture of the ligament and meniscus leading to laxity or locking * Serious systemic, oncohematological, autoimmune diseases; history of severe allergy; serious failure of vital organs, inability to walk * Hyaluronic acid infiltration within the previous six months * Hemoglobin levels \<10 g/dL;
Where this trial is running
Isfahan
- Leila Dehghani — Isfahan, Iran (Recruiting)
Study contacts
- Principal investigator: Leila Dehghani, Dr — Isfahan University of Medical Sciences
- Study coordinator: Leila Dehghani, Dr
- Email: l_dehghani2002@yahoo.com
- Phone: 36202020
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.