Using exosomes from stem cells to treat knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates the therapeutic potential of exosomes derived from mesenchymal stem cells (MSCs) in patients with knee osteoarthritis. The study aims to explore how these exosomes, which carry bioactive molecules, can suppress the progression of osteoarthritis by modulating inflammatory responses and promoting cartilage health. Participants will receive exosome treatments and will be monitored for improvements in knee pain and function. The study focuses on patients with chronic knee pain and specific radiographic findings of osteoarthritis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic history (for at least 3 months) of knee joint pain
* Body mass index (BMI) between 21.5 and 29.5
* Radiographically documented knee osteoarthritis of grades 1 to 3 (Kellgren-Lawrence (K-L) radiographic classification scale)

Exclusion Criteria:

* Rheumatoid arthritis and other rheumatic diseases
* Varus or valgus more than 10 degrees; lateral subluxation of the patella
* Deformity at the joint levels or adjacent to the knee due to fracture or any other injury
* Complete rupture of the ligament and meniscus leading to laxity or locking
* Serious systemic, oncohematological, autoimmune diseases; history of severe allergy; serious failure of vital organs, inability to walk
* Hyaluronic acid infiltration within the previous six months
* Hemoglobin levels \<10 g/dL;

Where it's running

• Leila Dehghani
  Isfahan, Iran Recruiting

Study contacts

• Principal investigator: Leila Dehghani, Dr — Isfahan University of Medical Sciences
• Study coordinator: Leila Dehghani, Dr
• Email: l_dehghani2002@yahoo.com
• Phone: 36202020

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.