Effects of TENS and exercise on knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of Transcutaneous Electrical Nerve Stimulation (TENS) combined with therapeutic exercises on individuals suffering from knee osteoarthritis. Participants will be randomly assigned to receive either TENS with exercises or a placebo treatment alongside the exercises. The study aims to evaluate pain relief and functional improvement in patients diagnosed with unilateral knee osteoarthritis. Inclusion criteria focus on individuals aged 40 and over with specific clinical symptoms and radiographic evidence of the condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* clinical diagnosis of unilateral osteoarthritis of the knee
* presenting knee pain for more than three months
* morning stiffness for less than 30 minutes
* crepitus, bone tenderness, and absence of palpable heat.

Exclusion Criteria:

* Bilateral knee osteoarthritis, hip osteoarthritis
* severe osteoporosis
* fibromyalgia
* medical history of tumors or cancer
* active inflammatory joint diseases (rheumatoid arthritis, gout),
* undergoing any lower extremity joint replacement
* neurological diseases (Parkinson's disease, Accident Cerebral Vascular, Multiple Sclerosis, muscular dystrophies, motor neuron disease, Alzheimer's disease)
* infected wounds or osteomyelitis in the knee region
* deep vein thrombosis or thrombophlebitis
* sensory changes in the lower limbs
* cognitive and cardiopulmonary impairment that may prevent or limit performing the exercises
* using a walking assistance device
* having a history of recent trauma to the knee,
* having undergone any form of treatment involving physiotherapy
* intra-articular corticosteroids, anti-inflammatories, or chondroprotective in the six months before the start of the interventions.

Where it's running

• Nove de Julho University
  São Paulo, Brazil Recruiting

Study contacts

• Principal investigator: Cid Gomes, PhD — Study Principal Investigator
• Study coordinator: Cid Gomes, PhD
• Email: cid.andre@gmail.com
• Phone: +5511970941936

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• SVF cellular mix, secretome, and knee response in osteoarthritis

  This study tests the cellular composition and secretome of research-only adipose-derived SVF in adults with knee OA who are already planned to receive an autologous SVF injection as part of their care.

  Recruiting Yonsei University · Seoul · NCT07898501

• Effect of a Resistance Exercise Program on IGF-1 Levels in Knee Osteoarthritis

  A structured 8-week resistance exercise program is being tested to see if it changes blood IGF-1 levels and improves knee OA symptoms in adults with knee OA and metabolic traits.

  Recruiting Sisli Hamidiye Etfal Training and Research Hospital · Istanbul, Istanbul · NCT07890155

• 2-mm subchondral drilling vs sequential 4-mm and 2-mm drilling during CARTISTEM implantation for knee cartilage defects

  This study tests whether drilling the knee with a 2-mm drill alone works as well as sequential 4-mm then 2-mm drilling when combined with CARTISTEM treatment for medial knee cartilage defects.

  Recruiting Yonsei University · Seoul · NCT07881445

• Undenatured Type II Collagen for Knee Osteoarthritis Pain (Three-Arm Trial)

  This study tests whether taking undenatured type II collagen capsules once daily for 4 months can reduce knee pain in adults with knee osteoarthritis, compared with two collagen formulations and a placebo.

  Recruiting Universidad Católica San Antonio de Murcia · Murcia, Murcia · NCT07870967

• Serum Fetuin‑A and COMP levels in knee osteoarthritis

  This study tests whether levels of Fetuin‑A and COMP in the blood relate to how severe knee osteoarthritis is in patients compared with healthy volunteers.

  Recruiting Antalya Training and Research Hospital · Antalya · NCT07706569

• Pain relief for knee osteoarthritis: a 2nd phase study of LY4065967 vs placebo

  Researchers are testing whether LY4065967 can help reduce knee pain from osteoarthritis in adults, compared with placebo.

  Recruiting at 36 sites Phase 2 Eli Lilly and Company · Birmingham, Alabama and 35 other locations · NCT07641517

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.