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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Comparing two techniques for total knee prosthesis installation

Official title: Mechanically or Kinematically Aligned Total Knee Prosthesis: Prospective and Comparative Study of Clinical, Stereoradiographic, and Biomechanical Results

Run by Clinique du Sport, Bordeaux Mérignac · NCT06158646 · Data updated 2026-11-12

This study is testing two different ways to install knee replacements to see which method helps patients feel better and have fewer problems after surgery.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment120 (estimated)
SponsorClinique du Sport, Bordeaux Mérignac
Academic / other
Locations1 site (Mérignac)
StatusRecruiting
StartedOctober 5, 2023
Main results expectedAugust 31, 2027
Study endsSeptember 30, 2027
Registry record updatedApril 6, 2026
Trial IDNCT06158646 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults who have undergone total knee arthroplasty and are being followed up one year post-surgery.

Probably not a fit

Patients with a contralateral knee prosthesis or other significant lower limb conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares two techniques for total knee prosthesis installation: Mechanical Alignment (MA) and Kinematic Alignment (KA). The MA technique uses fixed angles for bone cuts, which may lead to residual symptoms and dissatisfaction in patients. In contrast, the KA technique aims to restore the unique pre-arthritic anatomy of each knee, potentially improving clinical outcomes. The study will evaluate the effectiveness of these approaches in patients who have undergone total knee arthroplasty.

Why it matters

Potential benefit: If successful, this study could lead to improved patient satisfaction and reduced residual symptoms after total knee replacement.

How similar studies have gone: Previous studies have shown promising results with kinematic alignment techniques, suggesting potential for improved outcomes compared to traditional methods.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Patient followed as part of a consultation 1 year after TKA placement
* Adult patient
* Patient affiliated to a social security system
* Patient informed of the study and formally included (signing of informed consent) before the first research review

Exclusion Criteria:

* Patient with a contralateral knee prosthesis
* Patient with another condition (acquired pathology) of the lower limbs (e.g. severe osteoarthritis of the contralateral knee or hip/ankle) and/or of the nervous system (e.g. Parkinson's) which may significantly affect the quality of walking
* Pregnant patient
* Patient deprived of liberty by judicial or administrative decision,
* Adult patient subject to a legal protection measure or unable to express consent

Where it's running

  • Clinique du Sport Bordeaux Merignac
    Mérignac, France     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Osteoarthritis, Knee 66Clinique du Sport, Bordeaux Mérignac 9
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.