Understanding and treating lupus nephritis
Lupus nephritis: novel insights in the pathogenesis and treatment
This study is looking into what causes kidney problems in people with lupus and how we can better treat it, especially for kids and those from minority backgrounds, by examining urine samples to find out how the immune system affects the kidneys.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11046578 on NIH RePORTER |
What this research studies
This research investigates the causes and treatment options for lupus nephritis, a serious kidney condition that affects many patients with systemic lupus erythematosus, especially children and minorities. The study aims to identify how immune system interactions with kidney cells lead to inflammation and damage, using advanced techniques to analyze urine samples for molecular changes. By understanding these processes, the research seeks to develop targeted therapies that minimize side effects and improve treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and minorities diagnosed with systemic lupus erythematosus who are experiencing lupus nephritis.
Not a fit: Patients with lupus nephritis who do not have systemic lupus erythematosus or those with end-stage renal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for lupus nephritis, improving kidney health and quality of life for affected patients.
How similar studies have performed: Previous research has shown promise in understanding the immune mechanisms involved in lupus nephritis, but this approach aims to provide novel insights and targeted therapies.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Tsokos, George C — Beth Israel Deaconess Medical Center
- Study coordinator: Tsokos, George C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.