Understanding and treating lupus nephritis
Official title: Lupus nephritis: novel insights in the pathogenesis and treatment
Funded at Beth Israel Deaconess Medical Center · NIH-11046578 · Data updated 2026-11-12
This study is looking into what causes kidney problems in people with lupus and how we can better treat it, especially for kids and those from minority backgrounds, by examining urine samples to find out how the immune system affects the kidneys.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $2,211,044 |
| NIH project number | 5P01AI179405-02 |
| Project ID | NIH-11046578 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and minorities diagnosed with systemic lupus erythematosus who are experiencing lupus nephritis.
✕Less likely to help
Patients with lupus nephritis who do not have systemic lupus erythematosus or those with end-stage renal disease may not benefit from this research.
What this research studies
This research investigates the causes and treatment options for lupus nephritis, a serious kidney condition that affects many patients with systemic lupus erythematosus, especially children and minorities. The study aims to identify how immune system interactions with kidney cells lead to inflammation and damage, using advanced techniques to analyze urine samples for molecular changes. By understanding these processes, the research seeks to develop targeted therapies that minimize side effects and improve treatment outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for lupus nephritis, improving kidney health and quality of life for affected patients.
How similar studies have gone: Previous research has shown promise in understanding the immune mechanisms involved in lupus nephritis, but this approach aims to provide novel insights and targeted therapies.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Tsokos, George C — Beth Israel Deaconess Medical Center
- Study coordinator: Tsokos, George C
Related research
Other NIH-funded projects on the same topics.
-
Glycoprotein urine markers that signal lupus nephritis treatment response
A novel test uses urine glycoprotein patterns to show how well lupus nephritis is responding to standard treatment.
-
PTPRS and lupus nephritis: a new target to reduce kidney damage in lupus
Aims to understand how PTPRS contributes to kidney inflammation and scarring in lupus nephritis and explore targeting it to help patients.
-
Sodium’s effect on kidney B cells in lupus kidney disease
This grant explores how high sodium in the kidneys affects B cells in lupus nephritis and whether blocking a key cellular pump could reduce kidney damage.
-
Oral CD11b Activator for Lupus Nephritis
A new oral CD11b activating drug is being explored to help people with lupus nephritis by targeting immune pathways that cause kidney inflammation.
-
Objective classification of lupus nephritis using computer vision
A new computer vision tool uses deep learning to classify lupus nephritis from kidney tissue images to help doctors predict outcomes for patients with lupus.
-
AI-powered look at lupus nephritis in humans and mice
Researchers will use artificial intelligence to compare kidney tissue from people with lupus nephritis to tissue from mouse models, aiming to understand why treatments work differently in humans.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.