Improving kidney health in lupus nephritis by targeting cell death mechanisms
Official title: Targeting ferroptosis in renal tubular epithelial cells to improve outcomes of lupus nephritis
Funded at University of Florida · NIH-11017808 · Data updated 2026-11-12
This study is looking at how too much iron in kidney cells can cause harmful cell death in people with lupus nephritis, and it aims to find new ways to help improve kidney health for those affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $419,497 |
| NIH project number | 5R01DK136011-03 |
| Project ID | NIH-11017808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lupus nephritis who are experiencing kidney complications.
✕Less likely to help
Patients without lupus nephritis or those with other unrelated kidney diseases may not benefit from this research.
What this research studies
This research focuses on lupus nephritis, a serious kidney condition associated with systemic lupus erythematosus. It aims to understand how iron accumulation in kidney cells leads to a specific type of cell death called ferroptosis, which is particularly harmful to renal tubular cells. By investigating the biological mechanisms behind this process, the researchers hope to identify new therapeutic targets that could improve kidney function and patient outcomes. The study will utilize advanced techniques to analyze kidney tissue and patient serum to uncover the pathways involved in tubular injury.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect kidney function in patients with lupus nephritis.
How similar studies have gone: Previous research has shown promising results in targeting ferroptosis in other conditions, suggesting potential for success in this novel application.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Scindia, Yogesh — University of Florida
- Study coordinator: Scindia, Yogesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.