Understanding genetic signatures in lupus nephritis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the origins and clinical significance of two specific genetic signatures associated with systemic lupus erythematosus (SLE) in patients with lupus nephritis. Researchers will analyze blood samples to identify different cell populations and measure cytokine levels, correlating these findings with disease activity and clinical manifestations. The study will utilize flow cytometry and in vitro assays on peripheral blood mononuclear cells to gather comprehensive data on the immune response in affected individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Fulfilment of the EULAR/ACR classification criteria of SLE.
* 18 years of age or above.
* Incident or Flare biopsy-proven proliferative or membranous LN

Exclusion Criteria:

* Antiphospholipid syndrome nephropathy (APSN).
* Pregnancy at baseline (pregnancy during follow-up will not lead to exclusion).
* Anticipated non-adherence to therapy.
* Medical conditions interfering with outcome evaluations.
* Inability to read and/or sign the informed consent form.

Where it's running

• Cliniques universitaires Saint-Luc
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Frédéric Houssiau, Pr — Cliniques universitaires Saint-Luc- Université Catholique de Louvain
• Study coordinator: Frédéric Houssiau, Pr
• Email: frederic.houssiau@uclouvain.be
• Phone: +32 02 764 53 90

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.