Understanding how a tiny molecule affects lupus and kidney problems
miR-21 regulation of autoreactive B cell and lupus nephritis development
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-11139640
This research explores how a small molecule called miR-21 contributes to lupus and its effects on the kidneys.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11139640 on ClinicalTrials.gov |
What this research studies
Our bodies have tiny molecules called microRNAs, and one called miR-21 seems to be more active in people with lupus. This project aims to understand how miR-21 encourages the immune system to produce harmful antibodies that attack the body's own tissues. We are particularly interested in how this process leads to lupus and kidney problems. By uncovering these details, we hope to find new ways to help control the disease. This work could lead to new treatments for lupus.
Who could benefit from this research
Good fit: Patients with systemic lupus erythematosus (SLE), especially those with kidney involvement (lupus nephritis), could potentially benefit from future treatments developed from this research.
Not a fit: Patients without systemic lupus erythematosus or related autoimmune conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of new targeted therapies for systemic lupus erythematosus (SLE), a debilitating disease.
How similar studies have performed: Previous findings in mouse models have shown a role for miR-21 in autoimmune diseases, but the exact mechanisms in lupus are still being identified.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAHMAN, ZIAUR — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: RAHMAN, ZIAUR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.