Preventing heart disease in patients with lupus nephritis
Official title: Early and Personalized Cardiovascular Disease Preventive Care in Lupus Nephritis (EPiC-LN)
Funded at University of Wisconsin-Madison · NIH-10949235 · Data updated 2026-11-12
This study is looking to find better ways to prevent heart disease in Black patients with lupus nephritis, especially focusing on who might benefit most from certain treatments and how to make those treatments safer, particularly for young women who are pregnant.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $173,472 |
| NIH project number | 1K23AR084608-01 |
| Project ID | NIH-10949235 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lupus nephritis, particularly those who are Black and at risk for cardiovascular disease.
✕Less likely to help
Patients without lupus nephritis or those who do not have risk factors for cardiovascular disease may not benefit from this research.
What this research studies
This research focuses on improving cardiovascular disease prevention in patients with lupus nephritis, particularly among Black patients who are at higher risk. It aims to identify which patients are most likely to benefit from preventive therapies and how to tailor these treatments to individual risk factors. The project will also address concerns about the safety and efficacy of these therapies, especially for young women during pregnancy. By developing an implementation guide for clinicians, the research seeks to enhance decision-making and support the use of effective therapies to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of cardiovascular disease and improve survival rates for patients with lupus nephritis.
How similar studies have gone: Previous research has shown promising results in improving cardiovascular disease prevention strategies in similar patient populations, indicating that this approach has potential for success.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Garg, Shivani — University of Wisconsin-Madison
- Study coordinator: Garg, Shivani
Related research
Other NIH-funded projects on the same topics.
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PTPRS and lupus nephritis: a new target to reduce kidney damage in lupus
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Sodium’s effect on kidney B cells in lupus kidney disease
This grant explores how high sodium in the kidneys affects B cells in lupus nephritis and whether blocking a key cellular pump could reduce kidney damage.
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Oral CD11b Activator for Lupus Nephritis
A new oral CD11b activating drug is being explored to help people with lupus nephritis by targeting immune pathways that cause kidney inflammation.
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Objective classification of lupus nephritis using computer vision
A new computer vision tool uses deep learning to classify lupus nephritis from kidney tissue images to help doctors predict outcomes for patients with lupus.
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AI-powered look at lupus nephritis in humans and mice
Researchers will use artificial intelligence to compare kidney tissue from people with lupus nephritis to tissue from mouse models, aiming to understand why treatments work differently in humans.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.