Investigating B cells involved in lupus nephritis
Autoimmunity-Associated B Cells in Lupus Nephritis
This study is looking at special immune cells that can cause kidney problems in people with lupus, and it aims to learn how these cells work and what makes them harmful, so we can find better ways to treat lupus nephritis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11091641 on NIH RePORTER |
What this research studies
This research focuses on a specific type of immune cell called autoimmunity-associated B cells (ABC) that are increased during lupus nephritis. The study aims to understand how these cells develop and produce autoantibodies, which can cause kidney damage in lupus patients. Researchers will use advanced techniques to analyze the genetic and epigenetic changes in these cells and their interactions with other cells in the kidney environment. By identifying the signals that regulate these processes, the research hopes to uncover new therapeutic targets for treating lupus nephritis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lupus nephritis who are experiencing active disease.
Not a fit: Patients with lupus who do not have kidney involvement or those with other autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even prevent kidney damage in lupus nephritis patients.
How similar studies have performed: Other research has shown promising results in understanding B cell behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Barnas, Jennifer Lynn — University of Rochester
- Study coordinator: Barnas, Jennifer Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.