Understanding myeloid cells in lupus nephritis
Official title: Dissecting the heterogeneity and function of myeloid cells in lupus nephritis
Funded at Feinstein Institute for Medical Research · NIH-11000308 · Data updated 2026-11-12
This study is looking at how certain immune cells in the body, called macrophages, affect kidney problems in people with lupus, and it hopes to find new ways to treat this condition by understanding these cells better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | February 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $592,335 |
| NIH project number | 5R01DK131482-03 |
| Project ID | NIH-11000308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with lupus nephritis, particularly those who have not responded well to current treatments.
✕Less likely to help
Patients with lupus nephritis who are already receiving effective treatment or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research investigates the role of myeloid cells, particularly macrophages, in lupus nephritis, a serious kidney condition associated with systemic lupus erythematosus. By analyzing these cells at a single-cell level, the study aims to identify different subsets of myeloid cells and their functions in kidney injury. The research utilizes both human kidney tissue samples and animal models to explore how these cells contribute to the disease and whether they can be targeted for better treatment outcomes. The goal is to improve understanding of the disease mechanisms and potentially develop more effective therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lupus nephritis, potentially reversing kidney damage and enhancing patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding myeloid cell functions in other autoimmune diseases, suggesting that this approach could yield valuable insights in lupus nephritis as well.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Davidson, Anne — Feinstein Institute for Medical Research
- Study coordinator: Davidson, Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.