Understanding myeloid cells in lupus nephritis
Dissecting the heterogeneity and function of myeloid cells in lupus nephritis
This study is looking at how certain immune cells in the body, called macrophages, affect kidney problems in people with lupus, and it hopes to find new ways to treat this condition by understanding these cells better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-11000308 on NIH RePORTER |
What this research studies
This research investigates the role of myeloid cells, particularly macrophages, in lupus nephritis, a serious kidney condition associated with systemic lupus erythematosus. By analyzing these cells at a single-cell level, the study aims to identify different subsets of myeloid cells and their functions in kidney injury. The research utilizes both human kidney tissue samples and animal models to explore how these cells contribute to the disease and whether they can be targeted for better treatment outcomes. The goal is to improve understanding of the disease mechanisms and potentially develop more effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with lupus nephritis, particularly those who have not responded well to current treatments.
Not a fit: Patients with lupus nephritis who are already receiving effective treatment or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lupus nephritis, potentially reversing kidney damage and enhancing patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding myeloid cell functions in other autoimmune diseases, suggesting that this approach could yield valuable insights in lupus nephritis as well.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Davidson, Anne — Feinstein Institute for Medical Research
- Study coordinator: Davidson, Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.