Sodium’s effect on kidney B cells in lupus kidney disease
Official title: The Effect of Sodium (Na+) on Kidney B cells in Lupus Nephritis
Funded at Yale University · NIH-11385489 · Data updated 2026-11-12
This grant explores how high sodium in the kidneys affects B cells in lupus nephritis and whether blocking a key cellular pump could reduce kidney damage.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $166,104 |
| NIH project number | 5K08DK133496-05 |
| Project ID | NIH-11385489 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with lupus nephritis or related autoimmune kidney disease could benefit from future therapies arising from this work.
✕Less likely to help
Individuals without lupus or kidney involvement may not directly benefit from this specific research.
What this research studies
Lupus nephritis is a kidney complication of lupus that can lead to kidney failure. The project studies kidney-infiltrating B cells and how high sodium levels in the kidney environment influence their survival and behavior. It uses mouse models to see if blocking the Na+/K+-ATPase pump can reduce B cell infiltration and protein in the urine, potentially easing kidney damage. The research aims to uncover mechanisms that could point to new, kidney-focused treatments for people with lupus nephritis.
Why it matters
Potential benefit: If successful, this work could guide new strategies to protect kidneys in lupus patients by targeting B cells and sodium handling.
How similar studies have gone: Preclinical studies in mice suggest that targeting B cells and ionic balance can alter kidney inflammation and damage in lupus models.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Chernova, Irene — Yale University
- Study coordinator: Chernova, Irene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.