Immune cells in lupus-related kidney inflammation
Official title: Dissecting the heterogeneity and function of myeloid cells in lupus nephritis
Funded at Feinstein Institute for Medical Research · NIH-11247065 · Data updated 2026-11-12
This project looks at different immune cells called myeloid cells in kidneys to learn how they cause or repair damage in people with lupus nephritis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | February 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $658,149 |
| NIH project number | 5R01DK131482-04 |
| Project ID | NIH-11247065 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with lupus nephritis who are undergoing kidney biopsy or are willing to donate biopsy material or blood samples for research are the ideal candidates.
✕Less likely to help
People without lupus nephritis, or those who are not having biopsies and are unwilling to provide samples, are unlikely to participate or directly benefit from this project.
What this research studies
Researchers will examine kidney biopsy samples from people with lupus nephritis alongside well-characterized mouse models to find matching myeloid cell types. They will use single-cell technologies to identify distinct myeloid subsets and follow how those cells change during disease. Laboratory experiments in animals will test whether particular myeloid subsets drive kidney injury or help with repair. The team aims to link specific cell types to disease activity and identify targets that could be useful for new treatments.
Why it matters
Potential benefit: If successful, this work could reveal specific immune cell targets or biomarkers that lead to more effective, less toxic treatments for lupus nephritis.
How similar studies have gone: Earlier single-cell mapping in lupus nephritis has shown multiple myeloid subsets exist, but determining which subsets are harmful or protective is a newer and less-tested step.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Davidson, Anne — Feinstein Institute for Medical Research
- Study coordinator: Davidson, Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.