Understanding lupus nephritis at the cellular level using advanced techniques
Official title: Interrogating The Biology Of Human Lupus Nephritis Using Single Cell Resolution Spatial Transcriptomics
Funded at Seattle Children's Hospital · NIH-11060920 · Data updated 2026-11-12
This study is looking at kidney tissue from kids with lupus nephritis to better understand how the disease affects them, with the hope of finding new treatments that work better for their specific needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $825,415 |
| NIH project number | 5R01DK136980-02 |
| Project ID | NIH-11060920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pediatric and adult patients diagnosed with lupus nephritis who have not responded adequately to standard treatments.
✕Less likely to help
Patients with lupus nephritis who have already achieved clinical remission or those with other unrelated kidney diseases may not benefit from this research.
What this research studies
This research investigates the biology of lupus nephritis by analyzing human kidney tissue at a single-cell level. It aims to improve our understanding of the disease, particularly in pediatric patients who are at higher risk for kidney damage. By utilizing advanced spatial transcriptomics, the study seeks to overcome limitations of previous methods that often relied on animal models and lost important spatial information. The goal is to identify immune pathways that could lead to more effective, targeted therapies for lupus nephritis.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for lupus nephritis, particularly benefiting pediatric patients.
How similar studies have gone: Previous research using single-cell RNA sequencing has shown promise in understanding immune-mediated kidney diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Jackson, Shaun William — Seattle Children's Hospital
- Study coordinator: Jackson, Shaun William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.