Effects of Mycophenolate Mofetil and Cyclophosphamide on Lymphocyte Subsets in Lupus Nephritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how mycophenolate mofetil (MMF) and cyclophosphamide (CTX) affect lymphocyte subsets in patients diagnosed with proliferative lupus nephritis. Participants with biopsy-proven Class III/IV+/-V lupus nephritis will be randomized to receive either CTX or MMF alongside prednisolone for six months, followed by maintenance therapy. The study will measure lymphocyte subsets and serum cytokine profiles at multiple time points to compare the two treatment regimens and assess their correlation with relapse risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- 1. Patients with biopsy proven Class III/IV+/-V LN (ISN/RPS classification) and active nephritis as indicated by an increase of proteinuria \>1g/day and/or rise in serum creatinine by \>15% compared with baseline, with or without serological reactivation.

2\. Willing to give informed consent

Exclusion Criteria:

1. Patients who have received calcineurin inhibitors or proliferation signal inhibitors as maintenance immunosuppression in the preceding 3 months
2. Patients have received biologics therapy (e.g. rituximab, abatacept) in the preceding 12 months
3. Patients who are pregnant or lactating

Where it's running

• Queen Mary Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Desmond YAP, MD (HK)
• Email: desmondy@hku.hk
• Phone: 22554385

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.