Investigating how sodium affects kidney B cells in lupus nephritis
Official title: The Effect of Sodium (Na+) on Kidney B cells in Lupus Nephritis
Funded at Yale University · NIH-10907612 · Data updated 2026-11-12
This study is looking at how high sodium levels in the kidneys affect certain immune cells that can harm the kidneys in people with lupus nephritis, with the hope of finding new ways to help treat this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $166,104 |
| NIH project number | 5K08DK133496-03 |
| Project ID | NIH-10907612 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lupus nephritis who are experiencing kidney-related symptoms.
✕Less likely to help
Patients without lupus nephritis or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research focuses on lupus nephritis, a serious kidney condition associated with systemic lupus erythematosus (SLE). It examines how high levels of sodium in the kidneys influence the behavior and survival of B cells, which are immune cells that can contribute to kidney damage. By studying these interactions, the research aims to uncover mechanisms that could lead to new treatments for patients with lupus nephritis. The approach includes using animal models to observe the effects of sodium on B cell function and survival in the kidney environment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve kidney health in patients with lupus nephritis.
How similar studies have gone: Other research has shown promising results in understanding immune cell behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Chernova, Irene — Yale University
- Study coordinator: Chernova, Irene
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This grant explores how high sodium in the kidneys affects B cells in lupus nephritis and whether blocking a key cellular pump could reduce kidney damage.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.