Investigating how changes in IgG glycosylation affect kidney injury in lupus nephritis
Official title: IgG glycosylation in lupus nephritis
Funded at Tulane University of Louisiana · NIH-11080116 · Data updated 2026-11-12
This study is looking at how certain changes in antibodies might affect kidney health in people with lupus nephritis, hoping to find new ways to prevent kidney damage for those dealing with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | July 18, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00AI162843-04 |
| Project ID | NIH-11080116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with systemic lupus erythematosus, particularly those who are at risk of developing lupus nephritis.
✕Less likely to help
Patients with lupus who do not have systemic lupus erythematosus or those without any kidney involvement may not benefit from this research.
What this research studies
This research focuses on lupus nephritis, a severe kidney complication affecting many patients with systemic lupus erythematosus. It aims to identify specific changes in the glycosylation of IgG antibodies in patients with lupus nephritis compared to those without. By understanding how these altered antibodies interact with kidney cells, the study seeks to uncover mechanisms that lead to kidney damage. The research involves characterizing IgG glycosylation patterns and exploring the signaling pathways that contribute to kidney injury, potentially leading to new preventive strategies.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for patients at risk of developing kidney complications from lupus.
How similar studies have gone: Previous research has shown promising results in understanding the role of glycosylation in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Bhargava, Rhea — Tulane University of Louisiana
- Study coordinator: Bhargava, Rhea
Related research
Other NIH-funded projects on the same topics.
-
Glycoprotein urine markers that signal lupus nephritis treatment response
A novel test uses urine glycoprotein patterns to show how well lupus nephritis is responding to standard treatment.
-
PTPRS and lupus nephritis: a new target to reduce kidney damage in lupus
Aims to understand how PTPRS contributes to kidney inflammation and scarring in lupus nephritis and explore targeting it to help patients.
-
Sodium’s effect on kidney B cells in lupus kidney disease
This grant explores how high sodium in the kidneys affects B cells in lupus nephritis and whether blocking a key cellular pump could reduce kidney damage.
-
Oral CD11b Activator for Lupus Nephritis
A new oral CD11b activating drug is being explored to help people with lupus nephritis by targeting immune pathways that cause kidney inflammation.
-
Objective classification of lupus nephritis using computer vision
A new computer vision tool uses deep learning to classify lupus nephritis from kidney tissue images to help doctors predict outcomes for patients with lupus.
-
AI-powered look at lupus nephritis in humans and mice
Researchers will use artificial intelligence to compare kidney tissue from people with lupus nephritis to tissue from mouse models, aiming to understand why treatments work differently in humans.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.