Condition

IgG4-related Disease clinical trials and research

• 11Clinical trials
• 2NIH research projects
• 1New in 30 days
• 7Countries

Newest IgG4-related Disease clinical trials

All recruiting trials (11)

• Dermal priming to boost flu vaccine response in people on B cell depletion

  This study tests whether applying a topical cream with imiquimod on the skin around vaccination can boost the body’s response to the flu shot in people who are receiving B cell–depleting therapy.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07925996

• FAPI‑74 PET/CT versus FDG PET/CT for inflammation in FUO, IgG4‑RD, and axial spondyloarthritis

  This project will test whether [18F]-AlF-FAPI-74 PET/CT finds inflammation more accurately than standard [18F]-FDG PET/CT in people with fever of unknown origin, IgG4‑related disease, or axial spondyloarthritis.

  Recruiting Phase 2/3 Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07535554

• Anti-BCMA-CD19 CAR-T therapy for relapsed or refractory IgG4-related disease

  This trial will test a personalized CAR-T cell therapy that targets BCMA and CD19 in adults (18–75) whose IgG4-related disease has come back or not responded to standard treatments like steroids or rituximab.

  Recruiting Phase 2 Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07148791

• Comparing low- and higher-dose lenalidomide plus prednisone versus prednisone alone for active proliferative IgG4‑related disease

  This 52-week randomized trial will test whether adding 5 mg or 10 mg lenalidomide to prednisone helps adults with active proliferative IgG4‑related disease do better than prednisone alone.

  Recruiting Phase 2/3 Peking Union Medical College Hospital · Beijing · NCT07068165

• ACE1831 cell therapy for safety, effectiveness, and persistence in people with IgG4-related disease

  This trial will test ACE1831, an off-the-shelf gamma delta T cell therapy from healthy donors, to see if it is safe and helps adults with active IgG4-related disease.

  Recruiting at 11 sites Phase 1/2 Acepodia Biotech, Inc. · Atlanta, Georgia and 10 other locations · NCT07061938

• Evaluating PRG-1801 for treating difficult cases of Lupus Nephritis and IgG4-Related Disease

  This study is testing a new treatment called PRG-1801 to see if it can help adults with tough cases of Lupus Nephritis and IgG4-Related Disease feel better.

  Recruiting Early Phase 1 Tongji Hospital · Wuhan, Hubei · NCT06497387

• Evaluating PRG-2311 for treating difficult cases of Lupus Nephritis and IgG4-Related Disease

  This study is testing a new treatment called PRG-2311 to see if it can help people with tough cases of Lupus Nephritis and IgG4-Related Disease improve their kidney function and overall health.

  Recruiting Early Phase 1 Tongji Hospital · Wuhan, Hubei · NCT06497361

• Exploring a new drug for rare immune-related inflammatory diseases

  This study is testing a new drug called Filgotinib to see if it can help people with rare immune-related inflammatory diseases feel better and reduce their symptoms.

  Recruiting at 6 sites Phase 2 UMC Utrecht · Amsterdam and 5 other locations · NCT06285539

• Collection of samples from patients with rheumatic diseases

  This study is collecting samples from people with rheumatic diseases to help researchers learn more about these conditions and improve treatments in the future.

  Recruiting Meir Medical Center · Kfar Saba · NCT03473912

• Nationwide registry for IgG4-related disease in China

  This study is gathering information from patients with IgG4-related disease across China to better understand the condition and improve how it's treated.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT03023371

• Observational study of IgG4-related disease in China

  This study looks at how IgG4-related disease affects patients in China and how well they respond to standard treatment over at least six months.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT01670695

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Mass General IgG4-related Disease Center

  This center follows people with IgG4-related disease to learn how immune cells, antibodies, and the microbiome drive flare-ups and remissions.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11323975

• Identifying immune responses in a specific fibrotic disease

  This study is looking into how the immune system works in people with IgG4-related disease to find out what specific proteins might be causing the unusual immune responses, which could help improve treatments for patients like you.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10912567

Related topics

Quick answers

How many IgG4-related Disease clinical trials are recruiting right now?

11, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (7 trials), Israel (1 trial), Belgium (1 trial), Japan (1 trial), United States (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 2/3: 2, Early Phase 1: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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