Investigating antibodies linked to modified nucleosomes in lupus nephritis
Official title: Diagnostic utility of antibodies to post-translationally modified nucleosomes in lupus nephritis
Funded at University of Houston · NIH-10906078 · Data updated 2026-11-12
This study is looking at how certain antibodies in people with lupus nephritis can help doctors better understand the disease and improve diagnosis, using a new test that tracks these antibodies as the condition changes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $174,892 |
| NIH project number | 5R21AR082713-02 |
| Project ID | NIH-10906078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those experiencing renal involvement.
✕Less likely to help
Patients without a diagnosis of systemic lupus erythematosus or those with other unrelated autoimmune diseases may not benefit from this research.
What this research studies
This research focuses on understanding the role of antibodies against post-translationally modified nucleosomes in patients with lupus nephritis. It aims to improve diagnostic accuracy by exploring how these antibodies fluctuate with disease activity and their potential to serve as early indicators of the condition. The study employs a novel fluorescent bead-based assay to detect these antibodies, which may provide insights into disease mechanisms and improve patient management. By identifying specific autoantibodies, the research seeks to enhance the diagnostic specificity for systemic lupus erythematosus (SLE).
Why it matters
Potential benefit: If successful, this research could lead to more accurate and earlier diagnosis of lupus nephritis, improving patient outcomes.
How similar studies have gone: While the approach of studying antibodies to modified nucleosomes is relatively novel, previous research has shown promise in using autoantibodies for diagnosing autoimmune diseases.
Where this research is happening
-
University of Houston
Houston, United States Active
Researchers
- Principal investigator: Mohan, Chandra — University of Houston
- Study coordinator: Mohan, Chandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.