Condition
Long COVID clinical trials and research
As of November 12, 2026, Find a Trial lists 51 Long COVID clinical trials that are recruiting, at sites in 22 countries (most in United States (26), Canada (9), Luxembourg (2)). 1 was first registered in the last 30 days. By phase: Phase 2 (9), Phase 2/3 (3), Phase 3 (2), Phase 1 (2). The most active sponsors are VA Office of Research and Development (3), Icahn School of Medicine at Mount Sinai (3), ImmunityBio, Inc. (2). There are also 52 NIH-funded research projects on Long COVID, with $48.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 51Clinical trials
- 52NIH research projects
- 1New in 30 days
- 22Countries
Newest Long COVID clinical trials
All recruiting trials (51)
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Whole-body Cryotherapy for Fatigue in ME/CFS, Fibromyalgia, Long COVID
This study tests whether brief, repeated exposure to extreme cold can help reduce fatigue and related symptoms in adults with ME/CFS, fibromyalgia, or Long COVID compared to healthy controls.
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Fatigue Investigation Using Digital Outcomes
This study tests whether digital monitoring with a smartphone app and wearables can track fatigue in people with MS or long COVID, compared with healthy volunteers.
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Biomarker study to understand Long COVID using VIPER
This study tests biomarkers in people with Long COVID and those who recovered from COVID-19 to see how they can diagnose and track the condition over time.
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PERCEIVE-Outreach: A scalable care model to help people with Long COVID manage heart and lung symptoms
This study tests a remote care model to see if a personalized, telehealth-based exercise program helps adults with Long COVID feel better and move more.
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Testing PNMR plus standard care for long COVID
We’re trying PNMR along with standard care to see if it helps people with long COVID better than standard care alone.
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Combination therapy for Long COVID symptoms using valacyclovir, celecoxib, and Paxlovid
This study tests whether a three-drug combination can reduce Long COVID symptoms in adults compared with a placebo.
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Right-sided stellate ganglion block for persistent long COVID symptoms
This trial will test whether a single right-sided stellate ganglion block with bupivacaine can help adults with long COVID who have ongoing breathlessness, fatigue, and cognitive problems.
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Immunoadsorption blood filter for autoimmune long COVID
We will test a blood-filter treatment called immunoadsorption in people with long COVID who have specific autoantibodies to see if their fatigue and daily functioning get better.
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Acupuncture and Chinese herbal medicine to ease long COVID symptoms
This project will try acupuncture, with or without Chinese herbal medicine, in adults with long COVID to see if symptoms, function, and quality of life improve over eight weeks.
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Magnetic brain stimulation for fatigue and brain fog in long COVID
This trial will see if repetitive transcranial magnetic stimulation (rTMS) can reduce severe fatigue and improve concentration in adults with long COVID.
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Kisspeptin to measure GnRH neuron function in people with and without post-COVID-19 syndrome
We will give one intravenous kisspeptin dose and take frequent blood samples to see if people with post-COVID-19 syndrome have different GnRH/LH hormone responses than people who had COVID but did not develop long COVID.
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Voice biomarkers for Long COVID monitoring using the Long COVID Companion app
This study tests whether voice biomarkers collected through the Long COVID Companion app can reflect common Long COVID symptoms to help monitor patients remotely.
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Focused ultrasound to improve thinking in post‑COVID brain fog
This project will see if short, targeted pulses of ultrasound to a specific brain area can improve thinking, attention, and other cognitive symptoms in people with persistent brain fog after COVID‑19.
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Long COVID relief through learning mindfulness
This study will try an 8-week online recorded mindfulness program to see if it reduces stress and Long COVID symptoms in adults who continue their usual care.
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Mitochondrial oxygen use in blood, muscle, and skin of people with long COVID
Researchers will test whether mitochondria use oxygen differently in blood cells, muscle, and skin of people with long COVID compared with people who fully recovered after COVID-19.
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Anktiva for treating Long COVID symptoms
This will test whether Anktiva helps adults aged 18–69 who had confirmed COVID-19 and now have persistent or worsened Long COVID symptoms.
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Anktiva (N-803) for adults with long COVID
This will test whether Anktiva (N-803), an IL-15 superagonist, is safe and tolerable in adults ages 18–69 who have long COVID.
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Magnetic resonance and rapid brain stimulation for Long COVID cognitive and mood symptoms
This trial will test whether an accelerated outpatient magnetic brain stimulation (iTBS) can help reduce brain fog, depression, and anxiety in adults with Long COVID.
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Understanding long-term cognitive effects of COVID-19 in Veterans
This study is trying to understand how COVID-19 affects the thinking and mental health of Veterans over time to help find better treatments for those struggling with these issues.
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Hi-OxSR to treat post-COVID cognitive problems
This trial will test whether using the Hi-OxSR breathing device can help adults with long COVID who have ongoing cognitive problems and fatigue.
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Long Covid Revitalize — repurposed drugs upadacitinib and pirfenidone for persistent Long Covid symptoms
This trial tests whether the existing drugs upadacitinib or pirfenidone can help adults with Long Covid who have had symptoms for three months or more.
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Lower-body heat therapy to improve mobility after long COVID
This test will see if at-home lower-body heat therapy can improve mobility and metabolic and vascular health in people aged 50–90 with long COVID who have ongoing fatigue or reduced physical function.
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Imaging brain inflammation in people with long COVID symptoms
This study is testing if a brain scan can show signs of inflammation in people aged 18 to 70 who have neurological symptoms after COVID-19, and whether a treatment called IVIg can help them feel better.
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Effects of Osteopathic Manipulative Therapy on Long COVID symptoms
This study is testing whether Osteopathic Manipulative Therapy can help people with Long COVID feel better by reducing their symptoms over eight weeks.
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Functional and cognitive rehabilitation versus informational support for adults with Long COVID and chronic conditions
This trial will try a combined physical and cognitive rehab program versus weekly evidence-based messages to see if adults with Long COVID and pre-existing hypertension or diabetes walk farther, think clearer, and feel better overall.
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Analyzing MicroRNAs and Vitamin B12 in Long COVID Patients with Neurological Symptoms
This study is testing if changes in certain microRNAs and vitamin B12 levels in the blood can help understand and treat neurological symptoms like depression and fatigue in people who have long COVID.
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Taurine supplements for people with Long COVID
This trial will test whether taking taurine supplements can help reduce fatigue and neurocognitive symptoms in adults living with Long COVID.
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Evaluating Baricitinib for Long COVID Symptoms
This study is testing if the medication baricitinib can help adults with Long COVID feel better physically and mentally compared to a placebo.
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Non-invasive treatment for brain fog in Long COVID patients
This study is testing a new non-invasive treatment for brain fog in people with Long COVID to see if changes in oxygen and carbon dioxide levels can help improve their symptoms.
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Fasting to Treat Long Covid in Adults
This study is testing if a week of fasting can help adults with long COVID feel better by reducing inflammation and improving their health.
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Testing antiviral medications for Long Covid
This study is testing if two HIV antiviral medications can help adults with Long Covid feel better after having symptoms for at least six months.
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Using Lumbrokinase to treat Long Covid, Lyme Disease, and Chronic Fatigue Syndrome
This study is testing if a treatment called Lumbrokinase can help adults with Long Covid, Lyme Disease, and Chronic Fatigue Syndrome feel better and improve their quality of life.
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Hyperbaric oxygen therapy for Long COVID cognitive symptoms
This study will test whether hyperbaric oxygen therapy can improve lingering cognitive symptoms like brain fog and memory problems in adults who had COVID-19.
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Improving life for patients with chronic fatigue syndrome
This study is testing if two medications can help people aged 18-65 with chronic fatigue syndrome feel better and manage their symptoms.
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Rehabilitation program to reduce fatigue after COVID-19
This study is testing a new rehabilitation program called COVIDEx to see if it can help people with Long COVID feel less tired compared to standard care.
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Water-based exercise and cognitive training for long COVID recovery
This study is testing if a mix of water-based exercise and brain training can help Veterans with long COVID feel better and improve their neurological symptoms.
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Imaging brain activity in patients with depression after COVID-19
This study is trying to see how COVID-19 might affect brain activity in people who have depression after their infection.
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Mind-body intervention for people with Long COVID
This study is testing a mind-body program to see if it can help people with Long COVID feel better and improve their daily activities.
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Using sauna therapy to treat Long Covid symptoms
This study is testing whether using sauna therapy can help people with Long Covid feel less tired and improve their symptoms.
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Evaluating Anakinra for Long COVID Symptoms
This study is testing if anakinra, an anti-inflammatory medication, can help people with long COVID symptoms feel better.
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Home monitoring and molecular profiling of patients with long COVID focusing on lung issues
This study is testing a mobile app to help people with long COVID and lung problems track their symptoms and understand the biological reasons behind their condition.
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Improving smell function in long COVID patients through training and stimulation
This study is testing two at-home treatments to see if they can help people with long COVID regain their sense of smell and possibly improve other symptoms.
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Cardiac-coherence breathing training for adults with Long COVID in Réunion
This project will test whether a simple breathing-control method (cardiac coherence) helps adults in Réunion with Long COVID reduce symptoms and improve daily functioning.
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Investigating the links between obesity, insulin resistance, and long COVID
This study is trying to see if obesity and insulin resistance make long-lasting COVID-19 symptoms worse, by looking at fat tissue and its role in inflammation and the virus.
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Transcranial Direct Current Stimulation for Long COVID with Headaches and Chronic Pain
This study tests whether applying mild brain stimulation (tDCS) can help people with long COVID who have headaches, migraines, and ongoing pain.
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Treatment for cognitive impairments in long COVID patients
This study is testing whether a treatment called DAOIB can help people with long COVID who are struggling with thinking and memory problems feel better over 24 weeks.
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A study using wearable devices to manage Long COVID symptoms
This study is testing if using wearable devices can help people with Long COVID manage their symptoms and improve their quality of life.
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Investigating the long-term effects of COVID-19 in children
This study is testing the long-term effects of COVID-19 on children's brain health and mental well-being by looking at kids aged 6-18 who had the virus and comparing them to healthy peers.
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Rehabilitation for older Veterans recovering from long-COVID
This study is testing whether a new treatment can help older Veterans with long-COVID feel better by improving their blood vessel health and reducing fatigue and cognitive issues.
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A platform for collecting health data on ME/CFS and Long Covid
This study is trying to collect health information from adults with ME/CFS and Long Covid to help researchers better understand these conditions and improve future treatments.
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Observational study on post-COVID-19 complications
This study is trying to see what long-term health problems people might have after recovering from COVID-19, focusing on adults aged 18 to 100.
NIH-funded research (newest 40 of 52)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Defining neutrophil biology in pediatric Long COVID
This project looks at why some kids develop Long COVID by studying neutrophils to help find new ways to diagnose and treat the condition.
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Advancing Long COVID Care in Our Community through Access and Collaboration
A community-focused project to make long COVID care more accessible and equitable for people in St. Louis and rural Missouri.
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Pediatric Long COVID Care Network: Improving access and coordinated care for children
A nationwide pediatric program is testing a patient-centered, multi-disciplinary approach to help children with long COVID, especially in underserved communities.
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Comunidad: Expanding Long COVID care in underserved South Texas
A new program will broaden and coordinate Long COVID care for underserved communities in San Antonio and South Texas to improve access and outcomes.
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Atlanta Long COVID Coordinated Care Model for Diverse Populations
A regional program in Atlanta aims to improve access and coordination of care for people with Long COVID, especially in underserved communities.
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Long COVID Care Resources and Education to Improve Community Health
A program to support federally-qualified health centers in providing better Long COVID care through education, a shared hub, and easy referral pathways for underserved communities.
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Improving Access to Multidisciplinary Care for long COVID patients
A team at UW is expanding a long COVID clinic to help more patients get coordinated, multidisciplinary care—especially in rural areas and underserved communities.
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IMPACCT: Improving culturally relevant long COVID care and access
A program to train community healthcare providers and expand access to long COVID care for underserved and rural patients.
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Primary care–integrated Long COVID care to help minoritized adults in NYC
A patient-centered program will bring Long COVID care into primary care clinics in East Harlem to help adults who are minoritized or have lower incomes.
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Broadening access to a comprehensive Long COVID clinic for diverse groups
This grant aims to expand a multimodal Long COVID clinic to reach more diverse adults and connect them with ongoing care and research opportunities.
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Understanding why Long COVID affects women more than men
This project looks at why women are more likely to have Long COVID by studying immune responses in women who had COVID-19.
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Long COVID as a possible subtype of chronic fatigue syndrome
A study at a major hospital will look at whether Long COVID shares biology with chronic fatigue syndrome and what genetic and immune factors may link them.
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Understanding why some people have lasting thinking and mood problems after COVID-19
A study will follow adults who had COVID-19 to understand why some experience long-lasting memory, thinking, anxiety, or mood changes and what factors make it worse.
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Is Long COVID a subtype of chronic fatigue syndrome?
This project looks at whether people with Long COVID share the same genetic and immune signs as people with chronic fatigue syndrome by analyzing large collections of patient data.
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Bringing clear health information to PACS patients and providers in rural New England
A project to create easy-to-understand health information about post-acute COVID syndrome for patients and clinicians in rural northern New England.
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Quantitative Heart Scan to Find Coronary Microvascular Problems in Long COVID Patients
A heart MRI study will look for tiny blood vessel problems in people who have long-lasting COVID symptoms and chest pain.
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Early antiviral treatment to prevent long COVID
A proof-of-concept study will test whether starting a 14-day oral antiviral early in COVID-19 can prevent the long-term persistence of the virus and chronic inflammation that lead to Long COVID.
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Baricitinib for Long COVID-related memory and thinking problems
Seeing if the medicine baricitinib can help adults with Long COVID who have new or worsening memory, thinking, or breathing problems.
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Molecular signatures of Alzheimer’s, FTLD, and Long COVID in the brain
A scientist at UCLA will study brain tissue to find molecular patterns that link Alzheimer’s, a related dementia, and Long COVID, with the aim of understanding why certain brain areas are more affected.
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Biomarkers in saliva to predict Long COVID after COVID-19
A saliva-based test is being developed to identify people who are likely to develop Long COVID after acute COVID-19.
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Using nitrite supplements to help improve function and reduce fatigue in long COVID patients
This study is looking at whether drinking beetroot juice, which is high in nitrites, can help veterans with long COVID feel stronger and less tired, by comparing it to a placebo, to see if it improves their physical performance and overall well-being.
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Expanding Long COVID care and education for underserved communities
A Stanford-led Long COVID hub will work with community health centers to bring coordinated care, education, and specialist support to people with lingering COVID symptoms in underserved areas.
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Bringing better Long COVID care to St. Louis and rural Missouri
This project is expanding local Long COVID services and support so more people in St. Louis and rural Missouri can get timely diagnosis, treatment, and help with daily life.
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Primary care Long COVID care for underserved adults in New York City
This project creates a Long COVID clinic inside primary care to help adults from minoritized communities in New York City get faster, coordinated care.
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Expanded multidisciplinary care for people with long COVID
This project will expand the University of Washington long COVID clinic to make coordinated medical care, mental-health support, job/vocational help, and e-consults easier to access for people with long COVID, especially those in underserved and rural communities.
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Improving Health Information for Long COVID Patients in Rural Northern New England
This effort creates easy-to-understand health information for patients and healthcare providers dealing with Long COVID in rural areas of northern New England.
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Comunidad: Bringing better Long COVID care to underserved South Texas communities
This program will expand coordinated, culturally appropriate Long COVID care and outreach for people in San Antonio and rural South Texas who face barriers to medical and social services.
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Mid-Atlantic network to improve pediatric long COVID care
This project brings coordinated, family-centered specialty and community care to children and teens living with long COVID to help manage symptoms, support schooling, and improve access to services.
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Atlanta Long COVID coordinated care network
A citywide program in Atlanta that connects people with Long COVID to coordinated medical and behavioral health services through major hospitals and community partners.
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Long COVID may be a form of chronic fatigue syndrome
This project looks for shared genetic and immune causes in people with Long COVID and people with chronic fatigue syndrome to explain lingering symptoms.
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Treatment for long-term effects of COVID-19
This study is looking at a possible treatment using a compound called homotaurine to help people who are dealing with long-lasting brain fog, anxiety, and depression after having COVID-19, especially from the Omicron variant.
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Expanding Long COVID clinic services to reach more diverse patients
This project expands a team-based Long COVID clinic to provide coordinated care and easier access to research for people with ongoing symptoms after COVID-19, especially those from underserved communities.
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Enhancing Veterans’ Post-COVID Mobility with a Cognitive-Sensorimotor Gait Framework
A study to understand why some veterans have persistent gait and balance problems after COVID-19 and how cognitive and sensory factors contribute to mobility issues.
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Why some people have lasting thinking and mood problems after COVID-19
This project looks at whether ongoing inflammation after COVID-19 causes long-term memory, attention, anxiety, or depression problems in adults who were hospitalized with the virus.
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Understanding how CD8 T cells respond to SARS-CoV-2 and their role in Long COVID
This study is looking at how certain immune cells called CD8 T cells work to fight off COVID-19, especially in people who have lingering symptoms, to help find ways to improve vaccines and treatments for the virus and its long-term effects.
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Understanding how neutrophils affect Long COVID in children
This study is looking at how a type of white blood cell called neutrophils behaves in children with Long COVID, to help find better ways to diagnose and treat this condition.
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Water-based exercise and cognitive training for recovery in long COVID
This study is looking at whether a special program that combines water exercise and brain training can help Veterans with long COVID feel better, and it will compare this program to regular care to see how well it works and how much people like it.
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Investigating the use of Baricitinib to treat cognitive impairment after Long COVID
This study is looking for people who have memory and thinking problems after COVID-19 to see if a medication called Baricitinib can help improve their brain function and reduce symptoms of Alzheimer's and related conditions.
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Creating antibodies to study long-COVID in hamsters
This study is looking to create special antibodies that can help researchers learn more about how the immune system responds to long-COVID in hamsters, which could eventually help us understand the condition better for everyone.
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Improving access to care for patients with long COVID
This study is working to make it easier for people with long COVID, especially those in rural areas and certain ethnic communities, to get the care and support they need, including medical help, mental health services, job assistance, and connections to local resources.
Related topics
Quick answers
How many Long COVID clinical trials are recruiting right now?
51, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 22 countries. The most sites are in United States (26 trials), Canada (9 trials), Luxembourg (2 trials), Taiwan (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 9, Phase 2/3: 3, Phase 3: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.