Rehabilitation for older Veterans recovering from long-COVID

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to improve the health outcomes of older Veterans suffering from long-COVID by developing rehabilitation therapies that enhance vascular endothelial function. The approach focuses on addressing oxidative stress and inflammation, which are exacerbated by aging and COVID-19. Participants will receive either Mitoquinone or a placebo to evaluate the effectiveness of this treatment in improving symptoms associated with long-COVID, such as fatigue and cognitive deficits. The study will assess the long-term health impacts of COVID-19 and provide evidence-based recommendations for rehabilitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Long-COVID and COVID-recovered patients must have SARS-CoV-19 positive test near the time of COVID-19 diagnosis
* Long-COVID and COVID-recovered patients must be 3-12 months post-initial COVID-19 diagnosis
* Ability to sign informed consent

Exclusion Criteria:

* BMI \>45 kg/m2
* Unstable (\<6 months) or severe coronary artery disease (CAD-RADS score = 4A), peripheral artery disease (Ankle Brachial Index \<0.40), cerebrovascular disease (identified by previous stroke in last 12 months), severe COPD (=Stage III), uncontrolled hypertension (\>160/100 mmHg), chronic kidney disease requiring dialysis, severe renal insufficiency (creatinine clearance \<30 by the Cockcroft-Gault formula), Alzheimer's disease, dementia
* Orthopedic limitations that would prohibit exercise
* Current smokers and individuals that stopped smoking in the last 10 years
* Already taking Mito-Q or unwilling to cease dietary supplements for participation
* Any other condition or event considered exclusionary by the PIs or a physician

Where it's running

• VA Salt Lake City Health Care System, Salt Lake City, UT
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: Joel Douglas Trinity, PhD — VA Salt Lake City Health Care System, Salt Lake City, UT
• Study coordinator: Joel D Trinity, PhD
• Email: Joel.Trinity@va.gov
• Phone: (801) 582-1565

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Combination therapy for Long COVID symptoms using valacyclovir, celecoxib, and Paxlovid

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  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07597902

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.