Functional and cognitive rehabilitation versus informational support for adults with Long COVID and chronic conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with prior COVID-19 and pre-existing hypertension or type 2 diabetes who report at least two persistent Long COVID symptoms are randomized to either an eight-week, weekly in-person functional and cognitive rehabilitation program or to receive weekly evidence-based informational messages. The rehabilitation arm includes supervised physical exercises and structured cognitive activities delivered by clinical staff, while the control arm receives tailored educational content by message. Outcomes measured at baseline, after the 8-week intervention, and at six months include the six-minute walk test, handgrip strength, MoCA cognitive score, EQ-5D-5L quality of life, and incidence of events indicating worsening of underlying conditions. Participants are identified from institutional registries at Fundación Cardioinfantil and Hospital Militar Central and the intervention is conducted at Fundación Cardioinfantil in Bogotá.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Covid-19 confirmed.
* History of arterial hypertension or diabetes mellitus before entering the institutional registries of the FCI-IC or HOMIL, institutional registries of the FCI-IC or HOMIL or before having the diagnosis of SARSCoV-2 infection.
* Persistence of two or more concurrent symptoms, related to Covid-19 prologue, for at least 4 weeks (persistent, intermittent, or intermittent).
* At least one of these symptoms must have an impact on activities of daily living. They can be physical (fatigue, dyspnea, myalgias, arthralgias) or neuropsychiatric (cognitive, sleep and emotional alterations).
* Symptoms unexplained by underlying disease or other condition concomitant with SARS-CoV-2 infection. SARS-CoV-2 infection (determined by prior medical history review and participant interview).

participant interview).

\- Ability to read and attend functional and cognitive rehabilitation sessions or to receive the with evidence-based informational messages.

Exclusion Criteria:

* Age \>80 years.
* Severely advanced baseline comorbidities prior to SARS-CoV-2 infection.
* Presence of chronic respiratory disease (partial or permanent supplemental oxygen use), cardiac failure (LVEF\<40%) or advanced renal disease (GFR\<30%).

heart failure (LVEF\<40%) or advanced renal disease (GFR\<30).

* Two hospitalizations in the year prior to admission to the institutional registries of the FCI-IC and the HOMIL for the patient's underlying disease.
* Dependence on a caregiver.
* Orthopedic or cardiopulmonary problems that contraindicate the performance of aerobic exercise.
* Neuropsychiatric or cognitive limitations that limit understanding or following commands and performing attention exercises.

Where it's running

• Fundación Cardioinfantil-Instituto de cardiología
  Bogotá, Bogotá DC, Colombia Recruiting

Study contacts

• Study coordinator: Karen J Moreno, PT MSc
• Email: kmoreno@lacardio.org
• Phone: +6016672727

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.