Functional and cognitive rehabilitation versus informational support for adults with Long COVID and chronic conditions
Impact of Functional and Cognitive Rehabilitation, in Adults With Chronic Noncommunicable Diseases and Long Covid-19 , on Their Functional and Cognitive Capacity, Quality of Life, and the Evolution of Their Baseline Condition, in Bogotá D.C.
This trial will try a combined physical and cognitive rehab program versus weekly evidence-based messages to see if adults with Long COVID and pre-existing hypertension or diabetes walk farther, think clearer, and feel better overall.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 374 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Fundación Cardioinfantil Instituto de Cardiología Academic / other |
| Locations | 1 site (Bogotá, Bogotá DC) |
| Trial ID | NCT06871293 on ClinicalTrials.gov |
What this trial studies
Adults with prior COVID-19 and pre-existing hypertension or type 2 diabetes who report at least two persistent Long COVID symptoms are randomized to either an eight-week, weekly in-person functional and cognitive rehabilitation program or to receive weekly evidence-based informational messages. The rehabilitation arm includes supervised physical exercises and structured cognitive activities delivered by clinical staff, while the control arm receives tailored educational content by message. Outcomes measured at baseline, after the 8-week intervention, and at six months include the six-minute walk test, handgrip strength, MoCA cognitive score, EQ-5D-5L quality of life, and incidence of events indicating worsening of underlying conditions. Participants are identified from institutional registries at Fundación Cardioinfantil and Hospital Militar Central and the intervention is conducted at Fundación Cardioinfantil in Bogotá.
Who should consider this trial
Good fit: Adults (≥18) with confirmed prior COVID-19, a history of hypertension or type 2 diabetes, and at least two persistent Long COVID symptoms for four weeks or more that affect daily activities are ideal candidates.
Not a fit: Patients without persistent post-COVID symptoms, those without hypertension or diabetes, children, or people unable to attend weekly in-person sessions are unlikely to benefit from this specific intervention.
Why it matters
Potential benefit: If successful, the program could improve walking distance, cognitive performance, and quality of life while slowing worsening of chronic conditions in adults with Long COVID.
How similar studies have performed: Previous rehabilitation programs for Long COVID have shown modest improvements in physical function and symptoms, but combined structured functional and cognitive interventions remain relatively new and evidence is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Covid-19 confirmed. * History of arterial hypertension or diabetes mellitus before entering the institutional registries of the FCI-IC or HOMIL, institutional registries of the FCI-IC or HOMIL or before having the diagnosis of SARSCoV-2 infection. * Persistence of two or more concurrent symptoms, related to Covid-19 prologue, for at least 4 weeks (persistent, intermittent, or intermittent). * At least one of these symptoms must have an impact on activities of daily living. They can be physical (fatigue, dyspnea, myalgias, arthralgias) or neuropsychiatric (cognitive, sleep and emotional alterations). * Symptoms unexplained by underlying disease or other condition concomitant with SARS-CoV-2 infection. SARS-CoV-2 infection (determined by prior medical history review and participant interview). participant interview). \- Ability to read and attend functional and cognitive rehabilitation sessions or to receive the with evidence-based informational messages. Exclusion Criteria: * Age \>80 years. * Severely advanced baseline comorbidities prior to SARS-CoV-2 infection. * Presence of chronic respiratory disease (partial or permanent supplemental oxygen use), cardiac failure (LVEF\<40%) or advanced renal disease (GFR\<30%). heart failure (LVEF\<40%) or advanced renal disease (GFR\<30). * Two hospitalizations in the year prior to admission to the institutional registries of the FCI-IC and the HOMIL for the patient's underlying disease. * Dependence on a caregiver. * Orthopedic or cardiopulmonary problems that contraindicate the performance of aerobic exercise. * Neuropsychiatric or cognitive limitations that limit understanding or following commands and performing attention exercises.
Where this trial is running
Bogotá, Bogotá DC
- Fundación Cardioinfantil-Instituto de cardiología — Bogotá, Bogotá DC, Colombia (Recruiting)
Study contacts
- Study coordinator: Karen J Moreno, PT MSc
- Email: kmoreno@lacardio.org
- Phone: +6016672727
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.