Using nitrite supplements to help improve function and reduce fatigue in long COVID patients
Official title: Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients
Funded at Veterans Health Administration · NIH-11229567 · Data updated 2026-11-12
This study is looking at whether drinking beetroot juice, which is high in nitrites, can help veterans with long COVID feel stronger and less tired, by comparing it to a placebo, to see if it improves their physical performance and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | March 1, 2023 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5I21RX004409-03 |
| Project ID | NIH-11229567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans over the age of 21 who are experiencing long COVID symptoms, particularly those with muscle fatigue and decreased physical function.
✕Less likely to help
Patients who are not veterans or those who do not have long COVID symptoms may not benefit from this research.
What this research studies
This research investigates the effects of nitrite supplementation on veterans suffering from long COVID, a condition that often leads to decreased physical function and quality of life. The study will compare the effects of nitrate-rich beetroot juice to a placebo on improving muscle function and reducing fatigue. Participants will be monitored for changes in their physical performance, specifically looking at how nitrite levels in the body correlate with improvements in cardiorespiratory fitness and perceived exertion during exercise. The goal is to determine if this dietary intervention can enhance recovery and overall well-being in affected individuals.
Why it matters
Potential benefit: If successful, this research could provide a new dietary approach to alleviate symptoms of long COVID and improve the quality of life for patients.
How similar studies have gone: Previous research has shown promising results with nitrite supplementation in improving muscle function and exercise capacity, suggesting potential for success in this new application.
Where this research is happening
-
Veterans Health Administration
Pittsburgh, United States Active
Researchers
- Principal investigator: Forman, Daniel E. — Veterans Health Administration
- Study coordinator: Forman, Daniel E.
Related research
Other NIH-funded projects on the same topics.
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Defining neutrophil biology in pediatric Long COVID
This project looks at why some kids develop Long COVID by studying neutrophils to help find new ways to diagnose and treat the condition.
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Advancing Long COVID Care in Our Community through Access and Collaboration
A community-focused project to make long COVID care more accessible and equitable for people in St. Louis and rural Missouri.
-
Pediatric Long COVID Care Network: Improving access and coordinated care for children
A nationwide pediatric program is testing a patient-centered, multi-disciplinary approach to help children with long COVID, especially in underserved communities.
-
Comunidad: Expanding Long COVID care in underserved South Texas
A new program will broaden and coordinate Long COVID care for underserved communities in San Antonio and South Texas to improve access and outcomes.
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Atlanta Long COVID Coordinated Care Model for Diverse Populations
A regional program in Atlanta aims to improve access and coordination of care for people with Long COVID, especially in underserved communities.
-
Long COVID Care Resources and Education to Improve Community Health
A program to support federally-qualified health centers in providing better Long COVID care through education, a shared hub, and easy referral pathways for underserved communities.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.