Fatigue Investigation Using Digital Outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational study collects continuous data from wearables and a smartphone app to characterize daily fatigue patterns in people with multiple sclerosis or long COVID, plus healthy controls. Participants wear devices and complete at-home cognitive and motor tests over about eight weeks, alongside periodic clinic visits. The goal is to see if digital measures correlate with standard fatigue assessments and to explore additional factors like sleep and autonomic function. Primary focus is feasibility of sustained wearable use and data completeness; secondary aims examine relationships between digital metrics and clinical or self-reported fatigue, with exploratory analyses including machine learning models for fatigue estimation.

Why it matters

Who can join: the full rules

Inclusion Criteria Multiple Sclerosis or Long COVID

* Confirmed diagnosis of MS (by neurologist) or Long COVID (by medical doctor).
* Smartphone ownership.
* Provide written informed consent.
* Fluent in German or English.

Inclusion Criteria Healthy:

* Smartphone ownership.
* Provide written informed consent.
* Fluent in German or English.

Exclusion Criteria:

* Concomitant medication affecting fatigue or ANS such as antidepressants prescribed or adjusted 1 month before the initial visit.
* Unable to provide informed consent.
* Unwilling or unable to comply with the study protocol.
* Pregnancy or lactation.
* For controls: Diagnosis of any chronic disorders or diseases that may affect fatigue or ANS.
* For MS: Additional comorbidities that may affect fatigue or ANS such as autoimmune disease and cardiovascular disease.
* For long COVID: Additional comorbidities diagnosed prior to the first acute COVID-19 infection that may affect fatigue or ANS such as autoimmune disease and cardiovascular disease.

Where it's running

• Neurozentrum Basel Messeturm
  Basel, Basel, Switzerland Recruiting
• Bellevue Medical Group - Neurozentrum Sternen / Neurozentrum Bellevue
  Zurich, Canton of Zurich, Switzerland Recruiting
• University of Zurich
  Zurich, Canton of Zurich, Switzerland Recruiting
• NeuroPraxis Zürich GmbH
  Zurich, Canton of Zurich, Switzerland Recruiting
• Bellevue Medical Group - Neurozentrum Seefeld
  Zurich, Canton of Zurich, Switzerland Recruiting
• Klinik Lengg AG
  Zurich, Canton of Zurich, Switzerland Recruiting

Study contacts

• Study coordinator: Liliana Barrios, Dr. sc. ETH Zürich
• Email: fido@dsi.uzh.ch
• Phone: +41774141174

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.